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| 001 | 95737 | ||
| 003 | ES-MaUEC | ||
| 005 | 20230102112719.0 | ||
| 006 | m o d | ||
| 007 | cr cnu|||unuuu | ||
| 008 | 170404s2017 sz a o 001 0 eng d | ||
| 020 | _a3319460846 | ||
| 020 |
_a3319460862 _q(electronic bk.) |
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| 020 | _a9783319460840 | ||
| 020 |
_a9783319460864 _q(electronic bk.) |
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| 020 |
_z9783319460840 _q(print) |
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| 040 |
_aN$T _cN$T _dYDX _dEBLCP _dGW5XE _dN$T _dUAB _dDKU _dIOG _dOCLCF _dOCLCO _dAZU _dUPM _dMERER _dESU _dJBG _dIAD _dICW _dICN _dOCLCQ _dOCLCO _dVT2 _dOTZ _dOCLCO _dOCLCQ _dOCLCA _dU3W _dOCLCO _dES-MaUEC _bspa |
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| 050 | 4 |
_aQP572.T4 _b2017 EB |
|
| 245 | 0 | 0 |
_aTestosterone : _bfrom basic to clinical aspects _cAlexandre Hohl, editor. |
| 264 | 1 |
_aCham, Switzerland _bSpringer International Publishing _c2017 |
|
| 300 |
_a1 recurso en línea (xiii, 414 páginas) _bilustraciones (algunas a color) |
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| 336 |
_aTexto _btxt _2rdacontent |
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| 337 |
_aelectrâonico _bc _2rdamedia |
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| 338 |
_arecurso electrâonico _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 505 | 0 | _aPreface; Contents; Contributors; 1: The History of Testosterone and The Testes: From Antiquity to Modern Times; "The Oldest Key to the Endocrine Treasure Trove: The Testicles"; Effects of Testis Removal; Lessons from Experimental Testis Transplantation; Erroneous Conclusions from Berthold's Experiments; Testes for Organotherapy; Isolation and Synthesis of Testosterone; Evolution of Testosterone Preparations for Clinical Use; References; 2: Androgen Receptor in Health and Disease; Androgenic Hormones; Biosynthesis of Testosterone and 5[alpha]-Dihydrotestosterone ; Serum Testosterone. | |
| 505 | 8 | _aEarly AR-Dependent Events in Prostate Carcinogenesis Role of AR in Castration Resistant Prostate Cancer; AR and Breast Cancer; AR and Bone Health; Development of ARKO Mice; Specific Conditional Knock-Out of AR in the Testes; Sertoli Cell Specific ARKO Models; Leydig Cell-Specific ARKO Male Mice; Peritubular Myoid (PTM) Cell-Specific ARKO Mice; Germ Cell-Specific ARKO Male Mice; Function of AR in the Prostate and Accessory Glands; AR Functions in Prostatic Stroma; AR Functions in Prostatic Epithelium; AR Functions in Seminal Vesicles (SV); AR Functions in the Epididymis. | |
| 505 | 8 | _aEnzymatic Defects in Testosterone Synthesis17[beta]-Hydroxysteroid Dehydrogenase Type III Deficiency; 46,XY DSD with Normal or High Testosterone Secretion; Defects in the Conversion of Testosterone in Dihydrotestosterone: 5 Alpha Reductase 2 Deficiency; Defects in Testosterone Action: Androgen Receptor Defects; Management of Patients with 46,XY DSD; Hormonal Therapy in Patients With DSD with Male Social Sex; Surgical Procedures in Patients With DSD with Male Social Sex; References; 4: Utility and Limitations in Measuring Testosterone; Introduction. | |
| 505 | 8 | _aFunction of AR in Testicular Descent Functions of AR in Females; AR and Breast Development; AR and Uterus; AR and PCOS; References; 3: Physiology of Male Gonadotropic Axis and Disorders of Sex Development; Introduction; Control of Male Gonadotropic Axis Function; GnRH Secretion; LH Secretion; FSH Secretion; 46,XY Disorders of Sex Development; 46,XY DSD due to Low Testosterone Secretion; Defects in Formation of the Testes; 46,XY Gonadal Dysgenesis; Defects of Testosterone Production; LH/hCG Insensibility: Leydig Cell Hypoplasia; 46,XY DSD Due to Cholesterol Synthesis Defects. | |
| 505 | 8 | _aT and DHT Interact with AR in the Target Cell Two Ligands and One Receptor; Importance of Estrogens in the Male; The Androgen Receptor (AR); Background; Functional Domains of AR; DNA-Binding Domain (DBD) (Residues 555-623); Ligand Binding Domain (LBD, Residues 666-919); Hinge Region (Residues 624-665); AR Nuclear Export; Amino-Terminal Domain (NTD) (Residues 1-556); Receptor Dimerization; Coregulatory Proteins; AR in Clinical Medicine; AR PolyQ Repeat; Androgen Insensitivity Syndromes (AIS); AR and the Prostate; Prostate Embryogenesis. | |
| 520 | 3 | _aResearch on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use. This book addresses these topics, providing a broad overÂview about testosterone, from its basic feaÂtures to the most recent evidence of clinÂical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are assoÂciated with cardiovascular morbidity, metaÂbolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleteriÂous events. In general, there is increasing evidence that serum testosterone is a major biomarker status of menÌââs health in general. Testosterone: From Basic to Clinical Aspects is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharmaÂcology and physiology) through clinical aspects (related diseases and supplementation therÂapy). | |
| 650 | 7 |
_aHormonas sexuales _2embne _0(OCoLC)fst01148285 _0 _9675054 |
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| 700 | 1 |
_aHohl, Alexandre, _eeditor literario |
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| 856 | 4 | 0 |
_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-46086-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
| 988 | _aSpringer_Medicine_2017 | ||
| 998 |
_b02/2018 _dz _e- _zSI |
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| 999 |
_c95737 _d95737 _x1 |
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