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008			170403s2017 ne a o 001 0 eng d
020			_a9402410848 _q(electronic bk.)
020			_a9789402410846 _q(electronic bk.)
020			_z940241083X
020			_z9789402410839 _q(print)
040			_aN$T _cN$T _dGW5XE _dEBLCP _dYDX _dN$T _dNJR _dUAB _dIOG _dOCLCF _dOCLCO _dAZU _dUPM _dOCLCO _dMERER _dESU _dJBG _dIAD _dICW _dICN _dOCLCQ _dOCLCO _dVT2 _dOTZ _dOCLCO _dOCLCQ _dJG0 _dOCLCO _dOCLCA _dU3W _dOCLCO _dES-MaUEC _bspa
050		4	_aRC280.S5 _bS683 2017 EB
245	0	0	_aSquamous cell carcinoma : _bmolecular therapeutic targets _cSaman Warnakulasuriya, Zakir Khan, editors.
264		1	_aDordrecht, Netherlands _bSpringer _c2017.
300			_a1 recurso en línea _bilustraciones
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
500			_aIncluye índice
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505	0		_aPreface -- Foreword.-Introduction- The biology and pathology of squamous cell carcinomata in the head and neck -- Cancer Stem Cells -- Biopathology with reference to Head & Neck Cancers -- Hypoxia in head and neck cancer -- Genetic aberrations and molecular pathways in head and neck cancer -- p53 in Head and Neck Squamous Cell Carcinoma -- Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck -- Targeting the mTOR signaling circuitry in head and neck cancer -- Survivin as a Therapeutic Target in Squamous Cell Carcinoma -- MicroRNA: utility as biomarkers and therapeutic targets in squamous cell carcinoma -- Envoi -- An appraisal of Targeted Therapies for Head and Neck Cancer -- Index.
520	3		_aThis edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.
650		7	_aCarcinoma basocelular _2embne _0(OCoLC)fst01131075 _0 _9672622
700	1		_aKhan, Zakir, _d1979- _eeditor literario
700	1		_aWarnakulasuriya, S. _q(Saman), _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-94-024-1084-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017C
998			_b02/2018 _dz _e- _zSI
999			_c95729 _d95729 _x1