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008			170331t20172017sz ob 001 0 eng d
020			_a3319455141 _q(electronic bk.)
020			_a9783319455143 _q(electronic bk.)
020			_z3319455125
020			_z9783319455129
040			_aN$T _cN$T _dN$T _dEBLCP _dGW5XE _dYDX _dNJR _dOCLCF _dCOO _dAZU _dUPM _dUAB _dESU _dVT2 _dIOG _dJBG _dIAD _dICW _dICN _dOTZ _dOCLCQ _dU3W _dES-MaUEC _bspa
050		4	_aQP375.5 _b2017 EB
245	0	4	_aThe blood brain barrier and inflammation _cRuth Lyck, Gaby Enzmann, editors.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
264		4	_c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	0		_aProgress in inflammation research
504			_aIncluye referencias bibliográficas e índice
505	0		_aGeneral Introduction to Barrier Mechanisms in the Central Nervous System; 1 Introduction; 2 Barriers of the Brain; 3 Cellular Components of the Neurovascular Unit; 4 Influx Mechanisms of the Blood-Brain Barrier; 5 Efflux Mechanisms of the Brain Barrier Interfaces; 6 Brain Barriers Regulate CSF Secretion; 7 Conclusion; References; Topological Aspects of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers and Their Relevance in Inflammation; 1 Introduction; 2 Brain Inflammation in Human Diseases and Animal Models; 2.1 Multiple Sclerosis.
505	8		_a2.1 Alzheimer's Disease3 Amyotrophic Lateral Sclerosis; 3.1 Parkinson's Disease; 3.2 Huntington's Disease; 4 Conclusion; References; Leakage at Blood-Neural Barriers; 1 Rationale; 2 Measuring Vascular Permeability; 3 Basal Water and Solute Transport at Blood-Neural Barriers; 4 Pathophysiological Leakage; 5 The Paracellular Leakage Pathway; 6 The Transcellular Leakage Pathway; 7 Endothelial Signalling During BBB or BRB Leakage; 8 BBB/BRB Function and Dysfunction: Nature and Nurture; 9 Opening the BBB for Therapeutic Drug Delivery; 10 Conclusion; References.
505	8		_a2.2 An Animal Model for MS: Experimental Autoimmune Encephalomyelitis2.3 Lymphocyte Entry into the CNS; 2.4 BBB Permeability During CNS Inflammation; 2.5 Cortical Inflammation in MS; 2.6 The Two-Wave Model for Lymphocyte Entry; 2.7 Neuromyelitis Optica; 3 Topology of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers; 3.1 The Endothelial Side of the Barrier; 3.2 The Glial Side of the Barriers; 3.3 Water Movements in the Brain; 4 Barrier-Related Cellular Characteristics of Epithelial Cells of the Choroid Plexus and Vascular Endothelial Cells During Inflammation; 5 Conclusions; Literature.
505	8		_aBlood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology1 Introduction; 2 BBB Transporter Proteins; 2.1 ATP-Binding Cassette Transporters; 2.1.1 Subfamily A Member: CERP (ABCA1); 2.1.2 Subfamily B Member: MDR1/P-gp (ABCB1); 2.1.3 Subfamily C, Members: MRP1 (ABCC1) and MRP4 (ABCC4); 2.1.4 Subfamily G, Member BCRP (ABCG2); 2.2 Solute Carrier Transporters; 2.2.1 SLC2: Facilitative Glucose Transporter Family Member: GLUT1 (SLC2A1); 2.2.2 SLC7A-SLC3A2: Neutral Amino Acid Transporter (LAT1-4F2hc).
505	8		_aThe Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions1 The Blood-Brain Barrier; 2 The Extracellular Matrix of the CNS; 3 Laminin Receptors on Endothelium and Astrocyte Endfeet; 4 Contributions of the Basement Membranes to BBB integrity; 4.1 Genetic Defects; 4.2 Autoimmune Diseases; 4.2.1 Leukocyte Transmigration Across the Endothelial BM; 4.2.2 Leukocyte Transmigration Across the Parenchymal BM; 5 Conclusion; References; Pathophysiology of the Blood-Brain Barrier in Neuroinflammatory Diseases; 1 Introduction; 2 Multiple Sclerosis.
520	3		_aWithin the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.
650		7	_aSistema nervioso central _2embne _0(OCoLC)fst00834835 _0 _9144873
700	1		_aEnzmann, Gaby, _eeditor literario
700	1		_aLyck, Ruth, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-45514-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _e- _zSI
999			_c95697 _d95697 _x1