000 07728cam a2200529Ii 4500
999 _c95604
_d95604
_x1
001 95604
003 ES-MaUEC
005 20230102112712.0
006 m o d
007 cr |||||||||||
008 170317t20172017si a ob 001 0 eng d
020 _a9789811032332
_q(electronic bk.)
020 _a9811032335
_q(electronic bk.)
020 _z9789811032318
_q(hardcover ;
_qalk. paper)
020 _z9811032319
_q(hardcover ;
_qalk. paper)
040 _aN$T
_cN$T
_dMMU
_dOCLCO
_dN$T
_dGW5XE
_dN$T
_dEBLCP
_dYDX
_dOCLCQ
_dUAB
_dOCLCO
_dAZU
_dIOG
_dOCLCO
_dCOO
_dUPM
_dMERER
_dESU
_dOCLCO
_dJBG
_dIAD
_dOCLCO
_dICW
_dOCLCO
_dICN
_dOCLCO
_dOTZ
_dOCLCQ
_dTFH
_dOCLCQ
_dOCLCO
_dU3W
_dES-MaUEC
_bspa
050 4 _aQP624.75.P74
_bR869 2017 EB
245 0 0 _aRUNX proteins in development and cancer
_cYoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen, editors.
264 1 _aSingapore
_bSpringer
_c[2017]
264 4 _c2017
300 _a1 recurso en línea (xx, 515 páginas)
_bilustraciones (algunas a color)
336 _astill image
_bsti
_2rdacontent
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 0 _aAdvances in experimental medicine and biology
_x2214-8019
_vvolume 962
500 _aSpringerLink
504 _aIncluye referencias bibliográficas e índice
505 0 _6880-01
_aEvolution of RUNX genes. RUNX in invertebrates / S. Hughes, A. Woollard -- RUNX and CBF[beta] structure and biophysics of CBF[beta]/RUNX and its translocation products / Tahir H. Tahirov, John Bushweller -- Covalent modifications of RUNX proteins: structure affects function / Ezra Blumenthal, Sarah Greenblatt, Guang Huang, Koji Ando, Ye Xu, Stephen D. Nimer -- RUNX genes and mammalian development. The role of Runx1 in embryonic blood cell formation / Amanda D. Yzaguirre, Marella F.T.R. de Bruijn, Nancy A. Speck -- Runx1 structure and function in blood cell development / Constanze Bonifer, Elena Levantini, Valerie Kouskoff, Georges Lacaud -- Roles of Runx2 in skeletal development / Toshihisa Komori -- Mitotic gene bookmarking: an epigenetic mechanism for coordination of lineage commitment, cell identity and cell growth / Sayyed K. Zaidi, Jane B. Lian, Andre van Wijnen, Janet L. Stein, Gary S. Stein -- Roles of Runx genes in nervous system development / Jae Woong Wang, Stefano Stifani -- Runx family genes in tissue stem cell dynamics / Chelsia Qiuxia Wang, Michelle Meng Huang Mok, Tomomasa Yokomizo, Vinay Tergaonkar [and others] -- Roles of the RUNX1 enhancer in normal hematopoiesis and leukemogenesis / Wei-Siang Liau, Phuong Cao Thi Ngoc, Takaomi Sanda -- RUNX1 and CBF[beta] fusion proteins in leukemia. RUNX1-ETO leukemia / Shan Lin, James C. Mulloy, Susumu Goyama -- Clinical relevance of RUNX1 and CBFB alterations in acute myeloid leukemia and other hematological disorders / Klaus H. Metzeler, Clara D. Bloomfield -- Mechanism of ETV6-RUNX1 leukemia / Aishwarya Sundaresh, Owen Williams -- ETV6-RUNX1 + acute lymphoblastic leukaemia in identical twins / Anthony M. Ford Ph. D., Mel Greaves FRS -- Molecular basis and targeted inhibition of CBF[beta]-SMMHC acute myeloid leukemia / Lucio H. Castilla, John H. Bushweller -- RUNX and CBF[beta] in cancer and immune function. The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models / James C. Neil, Kathryn Gilroy, Gillian Borland, Jodie Hay, Anne Terry, Anna Kilbey -- RUNX1 and CBF[beta] mutations and activities of their wild-type alleles in AML / R. Katherine Hyde, Paul Liu, Alan D. Friedman -- Roles of RUNX in B cell immortalisation / Michelle J. West, Paul J. Farrell -- Roles of RUNX in Solid Tumors / Linda Shyue Huey Chuang, Kosei Ito, Yoshiaki Ito -- RUNX3 and p53: how two tumor suppressors cooperate against oncogenic ras? / Jung-Won Lee, Andre van Wijnen, Suk-Chul Bae -- RUNX and CBF[beta] in cancer and immune function. Runx3 and cell fate decisions in pancreas cancer / Martin C. Whittle, Sunil R. Hingorani -- Runx genes in breast cancer and the mammary lineage / Nicholas Rooney, Alessandra I. Riggio, Daniel Mendoza-Villanueva, Paul Shore [and others] -- Runx3 in immunity, inflammation and cancer / Joseph Lotem, Ditsa Levanon, Varda Negreanu, Omri Bauer, Shay Hantisteanu [and others] -- Roles of RUNX complexes in immune cell development / Takashi Ebihara, Wooseok Seo, Ichiro Taniuchi -- CBF[beta] and HIV infection / Dong Young Kim, John D. Gross -- Emerging roles for RUNX. Roles of RUNX in hippo pathway signaling / Antonino Passaniti, Jessica L. Brusgard, Yiting Qiao, Marius Sudol [and others] -- Roles of RUNX in hypoxia-induced responses and angiogenesis / Sun Hee Lee, Sarala Manandhar, You Mie Lee -- The emerging roles of RUNX transcription factors in epithelial-mesenchymal transition / Dominic Chih-Cheng Voon, Jean Paul Thiery -- A regulatory role for RUNX1, RUNX3 in the maintenance of genomic integrity / Vaidehi Krishnan, Yoshiaki Ito.
520 3 _a"This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy"--Publisher's description.
588 0 _aOnline resource; title from pdf title page (SpringerLink, viewed March 20, 2017).
588 0 _aVersión impresa
988 _aEBOOK, EBSPRINGER_2017C
650 7 _2embne
_aADN
_9140806
700 1 _aGroner, Yoram,
_eeditor literario
700 1 _aIto, Yoshiaki,
_eeditor literario
700 1 _aLiu, Pu Paul,
_eeditor literario
700 1 _aNeil, James C,
_eeditor literario
700 1 _aSpeck, Nancy A,
_eeditor literario
700 1 _aVan Wijnen, Andre J.,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-3233-2
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
880 8 _6505-00/(S
_a1.8 Conserved RUNX-Associated Biological Processes1.8.1 Regulation of€the€Transition from€Quiescence into€Proliferation; 1.8.2 Lineage Commitment and€Cell Fate Determination; 1.9 Conserved RUNX Molecular Pathways; 1.9.1 Interaction with€Cell Cycle Genes; 1.9.2 Interaction with€Wnt Signalling; 1.9.3 Interaction with€GATA Factors; 1.10 Conclusion; References; Part II: RUNX and CBFβ: Structure and Function; 2: Structure and€Biophysics of€CBFβ/RUNX and€Its Translocation Products; 2.1 Biochemical Properties of€CBFβ and€RUNX.
880 8 _6505-01/(S
_a2.2 Structures of€the€CBFβ Heterodimerization Domain and€the€Runt Domain2.3 Structures of€CBFβ-Runt Domain-DNA Complexes and€Mechanism of€CBFβ Regulation of€the€Runt Domain; 2.4 Mutagenesis Studies of€CBFβ and€the€Runt Domain, Including€Disease Associated Mutations in€the€Runt Domain; 2.5 Structural Basis of€Ets1 Activation by€Runx1; 2.6 Biochemical Properties of€CBFβ-SMMHC; 2.7 Structure/Function of€RUNX1-RUNX1T1 (AML1-ETO); References; 3: Covalent Modifications of€RUNX Proteins: Structure Affects Function; 3.1 Contents of€the€Chapter (Including 1 Figure and€1 Table).
942 _2lcc
_cLE
998 _b02/2018
_dz
_e-
_zSI