000			05219cam a2200445Ii 4500
001			95601
003			ES-MaUEC
005			20230102112712.0
006			m o d
007			cr cnu|||unuuu
008			170317s2017 sz ob 000 0 eng d
020			_a3319529455 _q(electronic bk.)
020			_a9783319529455 _q(electronic bk.)
020			_z3319529439
020			_z9783319529431 _q(print)
040			_aN$T _cN$T _dEBLCP _dGW5XE _dYDX _dN$T _dOCLCF _dDKU _dOCLCO _dCOO _dAZU _dUPM _dOCLCO _dMERER _dVT2 _dOCLCQ _dOCLCO _dOCLCQ _dOCLCO _dJG0 _dOCLCO _dOCLCA _dUAB _dOCLCO _dES-MaUEC _bspa
050		4	_aQP623 _b.N663 2017 EB
245	0	0	_aNon-coding RNAs in the vasculature _cThomas Thum, Stefanie Dimmeler, editors.
264		1	_aCham, Switzerland _bSpringer _c2017.
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	0		_aCardiac and vascular biology _x2509-7830
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas
505	0		_aPreface; Contents; 1: Regulation of Atherosclerosis by microRNAs; 1.1 Introduction; 1.2 miRNA-Mediated Regulatory Mechanisms; 1.2.1 Regulatory Mechanisms of miRNA Strands Derived from a Single Precursor; 1.2.2 RNA Sponges in the Regulation of miRNA Activity; 1.2.3 Circulating miRNAs: Messengers on the Move; 1.3 Regulation of Inflammatory Macrophage Activation by a miRNA Tandem; 1.4 Combined Roles of miR-126-3p and miR-126-5p in Endothelial Regeneration and Their Use in Therapeutic Approaches; 1.5 Lipoprotein-Mediated miRNA Transfer; 1.6 Conclusions and Future Work; References.
505	8		_a2.4 LncRNAs and Cholesterol Metabolism2.4.1 LeXis; 2.4.2 Lnc-HC and ApoA1-AS; 2.4.3 LncLSTR; 2.5 Concluding Remarks; References; 3: MicroRNAs in Diabetes and Its Vascular Complications; 3.1 Introduction; 3.2 MicroRNAs in Diabetes Mellitus; 3.2.1 Pancreas; 3.2.2 Adipose Tissue; 3.2.3 Muscle; 3.2.4 Liver; 3.3 MicroRNAs Modulating the Impact of Diabetes Mellitus on Bone Marrow and on Stem and Progenitor Cells; 3.4 MicroRNAs in Diabetic Cardiovascular Complications; 3.4.1 Microvascular Complications; 3.4.1.1 Nephropathy; 3.4.1.2 Retinopathy; 3.4.1.3 Neuropathy.
505	8		_a2: Noncoding RNAs in Cholesterol Metabolism and Atherosclerosis2.1 Introduction; 2.2 miRNAs Regulating HDL-C Metabolism and Reverse Cholesterol Transport; 2.2.1 miR-33a/miR-33b; 2.2.2 miR-33a/miR-33b and Atherosclerosis; 2.3 miRNAs and LDL-C Metabolism; 2.3.1 miRNAs That Regulate Cholesterol Biosynthesis and VLDL Secretion; 2.3.1.1 miR-122; 2.3.1.2 miR-30c in Lipid Metabolism and Atherosclerosis; 2.3.1.3 miR-33a/miR-33b; 2.3.1.4 miR-96/miR-182/miR-183; 2.3.2 miRNAs That Regulate LDLR Expression and LDL-C Clearance; 2.3.2.1 miR-148a; 2.3.2.2 miR-128-1; 2.3.2.3 miR-185.
505	8		_a3.4.2 Cardiac Disease3.4.3 Peripheral Vascular Disease; 3.5 MicroRNA as Circulating Biomarkers of Diabetic Cardiovascular Disease; 3.6 Concluding Remarks; References; 4: Noncoding RNAs in Ischemic Cardiovascular Disease and Repair Mechanisms; 4.1 Targeting miRNAs to Enhance Cell-Based Therapies; 4.2 Targeting miRNAs to Induce a Cardiac Phenotype in Pluripotent Stem Cells; 4.3 Targeting miRNAs to Facilitate Cardiac Regenerative Pathways; 4.4 MiRNAs in the Development and Progression of Heart Failure; 4.5 Long Noncoding RNAs in Cardiovascular Disease; References.
505	8		_a5: Circulating microRNAs as Novel Biomarkers in Cardiovascular Disease: Basic and Technical Principles5.1 Introduction; 5.2 MicroRNA Biogenesis and Function; 5.3 Circulating miRNAs; 5.3.1 miRNAs in Vesicles; 5.3.1.1 Apoptotic Bodies; 5.3.1.2 Microparticles; 5.3.1.3 Exosomes; 5.3.2 miRNAs in Protein Complexes; 5.3.3 miRNAs in Lipoprotein Complexes; 5.4 Quantification of Circulating miRNAs; 5.4.1 Sample Preparation; 5.4.1.1 Sample Processing and Handling; 5.4.1.2 RNA Isolation; 5.4.2 Data Normalisation; 5.4.3 Comprehensive Profiling of Circulating miRNAs.
520	3		_aThis book focuses on the importance of regulatory RNAs in the vasculature. The main topics discussed include the role of regRNAs in vascular development and angiogenesis, ischemic cardiovascular disease and repair mechanisms, diabetic and metabolic vascular disease, atherosclerosis and vascular inflammation, as well as diagnostics of vascular disease using circulating miRNAs. Lastly, it offers an overview of emerging topics such as microvesicle-mediated miRNA cellular trafficking and the vascular importance of long non-coding RNAs. It is an invaluable resource for academics, researchers and students working in the field of vascular biology.
650		7	_aARN _2embne _0(OCoLC)fst01741020 _0 _9144940
700	1		_aDimmeler, Stefanie, _eeditor literario
700	1		_aThum, Thomas, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-52945-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017C
998			_b02/2018 _dz _e- _zSI
999			_c95601 _d95601 _x1