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008			170317s2017 sz a o 001 0 eng d
020			_a331947507X _q(electronic bk.)
020			_a9783319475073 _q(electronic bk.)
020			_z3319475053
020			_z9783319475059 _q(print)
040			_aN$T _cN$T _dGW5XE _dN$T _dEBLCP _dYDX _dOCLCQ _dOCLCF _dNJR _dUAB _dAZU _dIOG _dCOO _dUPM _dMERER _dESU _dVT2 _dOCLCQ _dJBG _dIAD _dICW _dICN _dOTZ _dOCLCQ _dOCLCO _dU3W _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aQP552.B65 _b2017 EB
245	0	0	_aBone morphogenetic proteins : _bsystems biology regulators _cSlobodan Vukicevic, Kuber T. Sampath, editors.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
300			_a1 recurso en línea (xii, 445 páginas) _bilustraciones (algunas a color)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	0		_aProgress in inflammation research
505	0		_aPreface; Contents; List of Contributors; Historical Perspective of€Bone Morphogenetic Proteins; 1 Bone Formation: Auto-induction; 2 Matrix-Induced Bone Formation: A€Biological Cascade; 3 Discovery of€Bone Morphogenetic Proteins; 4 BMP Structure; 5 BMP Receptors; 6 BMP Preclinical Studies; 7 BMP-7 in€Articular Cartilage Repair; 8 BMPs Beyond Bone; 9 BMP Clinical Studies; 10 Conclusion; References; The Systems Biology of€Bone Morphogenetic Proteins; 1 BMPs During Development; 2 Structure and€Function; 3 BMP: In€Vitro and€In€Vivo Model Systems for€Endochondral Bone Differentiation.
505	8		_a2.3.1 BMP and€Osteoblasts2.3.2 BMP and€Chondrocytes; 2.3.3 BMP and€Mesenchymal Cells; 2.3.4 BMP and€Osteoclasts; 2.3.5 BMP and€Other Cell Types in€Skeletal System; 2.4 BMP and€Bone-Related Diseases; 3 Craniofacial Development; 3.1 Head Induction; 3.2 Facial Development and€Abnormalities; 3.2.1 BMP and€Cleft Lip; 3.2.2 BMP, Facial Cleft, and€Midline Structure; 3.2.3 BMP and€Cleft Palate; 3.3 Calvarial Vault and€Cranial Base; 3.3.1 BMP and€Skull Formation; 3.3.2 BMP and€Suture Formation; 3.3.3 BMP and€Cranial Base; 3.4 Mandibular Development and€Temporomandibular Joint Formation.
505	8		_a3.4.1 BMP and€Mandible3.4.2 BMP and€the€Temporomandibular Joint; 4 Perspective and€Conclusions; References; BMP and€BMP Regulation: Structure and€Function; 1 General Mechanisms for€BMP Binding to€BMP Type I€and€Type II Receptors; 2 General Mechanisms for€BMP Inhibition and€Antagonism; 3 Noggin-Mediated Antagonism; 4 Follistatin Family-Mediated Antagonism; 5 Chordin Family-Mediated Antagonism; 6 DAN Family-Mediated Antagonism; 7 Prodomain Interactions and€Latent Complex Formation; 8 Co-receptors, Signal Enhancers, and€Other Antagonists; 9 Summary of€BMP Regulation Through€Different Mechanisms.
505	8		_a4 Role of€BMPs in€Cartilage Repair and€Regeneration5 Role of€BMPs in€Bone Repair and€Regeneration; 6 BMPs in€Dentin Repair and€Regeneration; 7 BMP-7 in€Acute and€Chronic Kidney Failure; 8 BMPs in€Glucose Homeostasis; 9 BMP-7 and€Calcium and€Phosphate Homeostasis; 10 BMPs in€Iron Homeostasis; 11 BMPs' Role in€Rare Genetic Disorders; 12 BMP in€Oncology; 13 Conclusion; References; Embryonic Skeletogenesis and€Craniofacial Development; 1 Introduction; 2 Embryonic Skeletogenesis; 2.1 Developmental Stages of€Ossification; 2.2 BMP and€Osteogenesis; 2.3 Functional Studies in€Animal Models.
520	3		_aThis book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
650		7	_aProteínas morfogenéticas óseas _2embne _0(OCoLC)fst00835964 _0 _9677787
700	1		_aSampath, Kuber T., _eeditor literario
700	1		_aVukicevic, Slobodan, _d1951- _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-47507-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _e- _zSI
999			_c95597 _d95597 _x1