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020			_a3319474626 _q(electronic bk.)
020			_a9783319474625 _q(electronic bk.)
020			_z331947460X
020			_z9783319474601 _q(print)
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050		4	_aRC647.B5 _bP538 2017 EB
066			_c(S
245	0	0	_aPlatelets in thrombotic and non-thrombotic disorders : _bpathophysiology, pharmacology and therapeutics : an update _cPaolo Gresele, Neal S. Kleiman, José A. Lopez, Clive P. Page, editors.
264		1	_aCham, Switzerland _bSpringer _c2017.
300			_a1 recurso en línea (xiii, 1445 páginas) _bilustraciones (algunas a color)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505	0		_6880-01 _aForeword; Contents; Contents for Volume 2; Part I: Physiology; A Brief History of Blood Platelets: A Personal View; Introduction; The Discovery of Blood Platelets and Early Research; The 1960s; The 1970s; The 1980s and 1990s; References; Phylogeny of Blood Platelets; Introduction; Phylogeny of Platelets; Phylogeny of Platelet Molecules and Receptors; References; Platelet Morphology and Ultrastructure; Overall Morphology and Function of Platelets; Visualization of Platelets; The Resting Platelet Ultrastructure; The Open Canalicular System; The Dense Tubular System; Peroxisomes; Mitochondria.
505	8		_aAge- and Maturation-Related Platelet HeterogeneityHeterogeneity of Platelet Genetics; Heterogeneity of Activated Platelets (Procoagulant Platelets); Platelet Heterogeneity Within the Hemostatic Plug and Thrombus; References; Regulation of Platelet Adhesion Receptors; Introduction; Regulation of Platelet Integrins; Positive Regulators of Integrin Activation; ``Classical F́́luid-Phase Excitatory Platelet Agonists; ``Nonclassical É́xcitatory Agonists; Matrix-Associated Platelet Agonists Functioning Through Hemostatic Pathways; Platelet Agonists Functioning Through Non-hemostatic Pathways.
520	3		_aThis book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.
650		7	_aPlaquetas sanguíneas _2embne _0(OCoLC)fst00834779 _0 _9677737
700	1		_aGresele, Paolo, _d1953- _eeditor literario
700	1		_aKleiman, Neal S., _eeditor literario
700	1		_aLopez, José A., _eeditor literario _934109
700	1		_aPage, C. P., _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-47462-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
880	8		_6505-00/(S _aPrincipal Signaling Pathways Downstream of Agonist Receptors Involved in Activation of αIIbbeta3Integrin-Proximal Regulatory Events; Negative Regulators of Integrin Activation; Proteins that Prevent Basal Activation of Integrins; Proteins that Promote Integrin Deactivation by Their Presence; Regulation of Non-integrin Platelet Adhesion Receptors; Perspective; References; The Platelet Glycoprotein Ib-IX-V Complex; Introduction; GPIb-IX-V Complex Structure and Biosynthesis; Polypeptide Structures; Functions of the Complex; GPIb-IX-V Complex Signaling; Summary; References.
880	8		_6505-00/(S _aα-GranulesDense Granules; Lysosomes; Platelet Cytoskeleton; Platelet Microparticles (PMPs) and Exosomes; Future Perspectives; References; Megakaryocyte Development and Platelet Production; Megakaryocyte Development; Commitment to the Megakaryocyte Lineage; Polyploidization; Cytoplasmic Maturation; Platelet Formation; The Proplatelet Theory; Morphogenesis of Proplatelets; The Cytoskeleton Powers Platelet Production; Release of Individual Platelets; Regulation of Platelet Formation In Vivo; Conclusion; References; Platelet Heterogeneity; Platelet Size Heterogeneity.
880	8		_6505-01/(S _aαIIbbeta3 (GPIIb/IIIa) Structure and FunctionIntroduction; αIIbbeta3 Biosynthesis; Structure of the αIIbbeta3 Extracellular Domains; αIIbbeta3 Activation; Intramolecular Interactions Involving the αIIb and beta3 Cytoplasmic Domains; Heteromeric Interaction of the αIIb and beta3 TM Domains; Protein Binding to the beta3 Cytoplasmic Domain Causes αIIbbeta3 Activation; αIIbbeta3-Mediated Outside-In Signaling in Platelets; Ligand Binding to αIIbbeta3; References; GPVI; Key Discoveries; GPVI Structure; The GPVI Receptor-Signalling Pathway; GPVI Ligands; GPVI in Platelet Physiology.
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017C
998			_b02/2018 _dz _e- _zSI
999			_c95563 _d95563 _x1