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020 _a3319337033
_q(electronic bk.)
020 _a9783319337036
_q(electronic bk.)
020 _z3319337017
020 _z9783319337012
_q(print)
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050 4 _aRC862.I53
_b2017 EB
245 0 0 _aCrohn's disease and ulcerative colitis :
_bfrom epidemiology and immunobiology to a rational diagnostic and therapeutic approach
_cDaniel C. Baumgart, editor.
250 _aSecond edition.
264 1 _aCham, Switzerland
_bSpringer International Publishing
_c2017
300 _a1 recurso en línea (xx, 695 páginas)
_bilustraciones
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
504 _aIncluye referencias bibliográficas e índice
505 0 _aForeword; Preface to the Second Edition; Preface; Contents; Contributors; Part I: Epidemiology; 1: Environmental Factors in€the€Epidemiology of€Inflammatory Bowel Disease; Introduction; Geography; Variation Between Countries; Variations Within€European Countries: Population-Based Studies (Fig.€1.7); Relationship Between UC and€CD; Environmental Factors; Relationship to€Microbiology; Relationship Between€Environment and€Geography; Socioeconomic Factors; Smoking; Nutrition and€Diet; Microparticles and€Pollution; Nonsteroidal Anti-inflammatory Drugs; Oral Contraceptives.
505 8 _aEffects of€Genes Versus the€Environment How Decisive Are Commensal Bacteria?; Loss of€Intestinal Immune Homeostasis in€IBD; Alterations of€Mucosal IgA and€Epithelial Barrier Function; Antibodies to€Commensals and€Abrogated Tolerance; Conclusions; References; 3: Understanding the€Epithelial Barrier in€IBD; The Epithelial Barrier Is Regulated in€Response to€Physiologic Stimuli; The Intestinal Barrier Is Compromised in€IBD; The Epithelial Monolayer; Molecular Anatomy of€the€Tight Junction; Intercellular Junctions and€IBD; Barrier Defects and€Mucosal Immune Regulation.
505 8 _aFormation and€Properties of€Secretory Antibodies The Epithelial Barrier Function; Additional IgA Antibody Functions; Effect of€Microbial-Host Interactions on€Innate and€Adaptive Immunity; The Epithelial Barrier and€Secretory Immunity; The Role of€Mucus in€Intestinal Barrier Function; Interactions of€SIgA with€Commensal Bacteria; Role of€IgA and€Breastfeeding in€Immune Control; Mucosal Homeostasis Versus€Hypersensitivity; Oral Tolerance in€Humans; Mucosal Tolerance Induction; Recognition of€Microbial Components; Innate Signals Dictating Homeostasis.
505 8 _aIsolated Barrier Defects Are Insufficient to€Cause Disease A Multifactorial Model of€IBD; Barrier Restoration as€a€Future Therapeutic Intervention; References; 4: Intestinal Microbiology and€Ecology in€Crohn's Disease and€Ulcerative Colitis; Structure and€Functionality of€the€Intestinal Microbiota; Factors Influencing the€Intestinal Microbiota Composition; The Role of€the€Intestinal Microbiota in€IBD; Intestinal Microbiota Composition in IBD; Genetic Background Contribution in€IBD; Intestinal Microbiota-Immune System Interaction in€IBD.
505 8 _aSeasonal Variability Appendectomy and€Tonsillectomy; General Remarks and€Future Aspects Regarding€Global Environmental Risk Factors in€IBD; References; Part II: Immunobiology; 2: Role of€the€Intestinal Immune System in€Health; Introduction; Induction and€Regulation of€Intestinal Immunity; Mechanisms Promoting Homeostasis; Inductive Gut-Associated Lymphoid Tissue Structures; Activation and€Homing of€Intestinal B Cells; Regional Intestinal Immune Differences; Intestinal Immunity in Infancy; Secretory Immunity and€the€Epithelial Barrier Function.
520 3 _aThis new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohnℓ́ℓs Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohnℓ́ℓs disease, ulcerative colitis, and related autoimmune disorders.
650 7 _aIntestinos
_xEnfermedades
_2embne
_0(OCoLC)fst00883883
_0
_9185357
700 1 _aBaumgart, Daniel,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-33703-6
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988 _aSpringer_Medicine_2017
998 _b02/2018
_dz
_e-
_zSI
999 _c95560
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