000 06343cam a2200421Ii 4500
001 95499
003 ES-MaUEC
005 20230102112707.0
006 m o d
007 cr cnu|||unuuu
008 170303s2017 ja a o 000 0 eng d
020 _a4431564632
_q(electronic bk.)
020 _a9784431564638
_q(electronic bk.)
020 _z4431564616
020 _z9784431564614
_q(print)
040 _aN$T
_cN$T
_dGW5XE
_dN$T
_dIDEBK
_dEBLCP
_dYDX
_dOCLCF
_dNJR
_dIOG
_dAZU
_dUPM
_dMERER
_dESU
_dOCLCQ
_dJBG
_dIAD
_dICW
_dICN
_dCOO
_dOTZ
_dOCLCQ
_dJG0
_dU3W
_dES-MaUEC
_bspa
050 4 _aQP532
_b.M483 2017 EB
245 0 0 _aMetallomics :
_brecent analytical techniques and applications
_cYasumitsu Ogra, Takafumi Hirata, editors.
264 1 _aTokyo, Japan
_bSpringer
_c2017.
300 _a1 recurso en línea (viii, 364 páginas)
_bilustraciones (algunas a color)
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
500 _aSpringerLink
_bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505 0 _aPreface; Contents; Part I: Overview; Chapter 1: Metallomics: Integrated Biometal Science; 1.1 Introduction; 1.2 Progress of Analytical Atomic Spectrometry; 1.3 All-Element Present Theory; 1.4 Chemical Speciation of Trace Metals in Biological Samples; 1.5 Human Genome Project and the Rapid Rise of Omics Science; 1.6 Proposal of Metallomics as Integrated Biometal Science-Historical Aspects; 1.7 International Symposium on Metallomics; 1.8 Progress of Metallomics Research; 1.8.1 The Scientific Journal of Metallomics; 1.8.2 Essentiality and Toxicity of the Elements.
505 8 _a1.8.3 A Simplified Model of the Biological System1.8.4 Scientific Fields in Trace Metal Science; 1.8.5 Research Subjects in Metallomics; 1.9 Summary; References; Part II: Analytical Techniques and Strategies Surrounding Metallomics; Chapter 2: Speciation and Identification of Chalcogen-Containing Metabolites; 2.1 Introduction; 2.2 Hyphenated Techniques; 2.3 Identification of Chalcogen-Containing Metabolites; 2.3.1 Selenosugars; 2.3.2 Selenohomolanthionine; 2.3.3 Selenoneine; 2.3.4 Selenocyanate; 2.3.5 Trimethyltelluronium Ion; 2.3.6 Te-Methyltellurocysteine; 2.4 Conclusion; References.
505 8 _a3.3.7 Application in Metal Transport with Targeting3.3.8 Transporter; 3.3.9 Cell-Penetrating Peptides (CPPs); 3.4 Future SXFM; 3.4.1 Improvement of X-Ray Sources; 3.4.2 High-Resolution SXFM; 3.4.3 Possible Labeled Probes; 3.4.4 Application of Medical Probes to SXFM; 3.4.5 SXFM Application for Different Types of Microscopy; 3.5 Collaboration on Platforms in Different Fields; 3.6 Conclusion; References; Chapter 4: Quantitative Elemental Bioimaging Protocol Using Femtosecond-Laser Ablation-ICP-Mass Spectrometry Coupled with Glas ... ; 4.1 Introduction; 4.2 Experimental Protocols.
505 8 _a4.2.1 Instrumentations4.2.2 Sample Preparations; 4.2.3 Experiment Procedures; 4.3 Results and Discussion; 4.3.1 Calibration Strategy; 4.3.2 Ablated Volume; 4.3.3 Quantitative Imaging; 4.4 Conclusion; References; Chapter 5: Single Cell Analysis by Using ICP-MS; 5.1 Introduction; 5.2 Overview of Cytometric Analysis by Using ICP-MS; 5.3 ICP Mass Spectrometers for Cytometric Analysis; 5.4 Cell Introduction Devices for Cytometric Analysis; 5.5 Application of Cytometric Analysis by Using ICP-MS; 5.5.1 Highly Sensitive Elemental Analysis by Time-Resolved ICP-MS; 5.5.2 Mass Cytometry.
505 8 _aChapter 3: Visualization of Intracellular Elements Using Scanning X-Ray Fluorescence Microscopy3.1 Imaging Intracellular Elements at the Single-Cell Level Provides New Insights; 3.2 Scanning X-Ray Fluorescence Microscopy; 3.2.1 Synchrotron Radiation X-Ray Source; 3.2.2 X-Ray Focusing Optics; 3.2.3 Demonstration of SXFM Performance; 3.3 Applications in Biology and Medicine; 3.3.1 SXFM Is Now User-Friendly; 3.3.2 Sample Preparation; 3.3.3 Basement for Cells; 3.3.4 Element Array; 3.3.5 A Cell Line Subjected to Sample Imaging at the Single-Cell Level; 3.3.6 Clinical Samples.
520 3 _aThis book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals. This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.
650 7 _9138327
_aMetales
_xMetabolism.
_2fast
_0(OCoLC)fst01018160
_0
700 1 _aHirata, Takafumi,
_eeditor literario
700 1 _aOgra, Yasumitsu,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-4-431-56463-8
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988 _aEBOOK, asignarmaterias, EBSPRINGER_2017C
998 _b02/2018
_dz
_e-
_zSI
999 _c95499
_d95499
_x1