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008			170228s2017 sz o 000 0 eng d
020			_a3319512846 _q(electronic bk.)
020			_a9783319512846 _q(electronic bk.)
020			_z331951282X
020			_z9783319512822 _q(print)
040			_aN$T _cN$T _dIDEBK _dEBLCP _dGW5XE _dN$T _dYDX _dDKU _dOCLCF _dCOO _dUAB _dIOG _dAZU _dVT2 _dUPM _dXPJ _dESU _dZ5A _dJBG _dIAD _dICW _dICN _dILO _dOTZ _dUX0 _dOCLCQ _dMERER _dOCLCQ _dOCLCO _dOCLCQ _dUV1 _dJG0 _dU3W _dES-MaUEC _bspa
050		4	_aTP248.27.M37 _bB584 2017 EB
245	0	0	_aBlue biotechnology : _bfrom gene to bioactive product _cWerner E.G. Müller, Heinz C. Schröder, Xiaohong Wang, editors.
264		1	_aCham, Switzerland _bSpringer _c2017.
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	0		_aProgress in molecular and subcellular biology. Marine molecular biotechnology _x0079-6484 _vvolume 55
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas al final de cada capítulo
505	0		_aPreface; Contents; Contributors; 1 35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters; Abstract; 1 Natural Product Research; 2 Marine Natural Product Research, a Field on the Rise; 3 Cold Waters, from the Shallow to the Deep; 4 Swedish Cold Waters; 5 The Emergence of Marine Pharmacognosy in Sweden; 6 Discovery of the Barettins from the Deep-Sea Sponge Geodia barretti; 7 Geodia barretti-A Sponge Model for Sponge Ground Investigations; 8 Cold-Water Temperatures Still Produce Cool Chemistry; 9 Interpretation, Prediction and Selection; 10 Conclusion.
505	8		_a3.2 Second Series of New Synthetic Analogues of Plakortin3.3 New Natural Polyketide Endoperoxides; 3.4 Synthetic Analogs of Aplidinone A and B; 4 Conclusion; Acknowledgments; References; 5 Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification; Abstract; 1 History of Natural Products in Medicine; 2 The Role of Natural Products in Nature; 3 The Antibiotic Crisis and the Need for New Medicine; 4 Antibiotic Resistance; 5 Natural Products and the Clinic. Towards New Antibiotics in the Battle Against Resistance.
505	8		_a4.1 Chemical Tactics-Where to Get First Hits?4.2 Biological Tactics-Screening Cascade; 5 Drug Development; 6 Preclinical Development; 7 Clinical Development; 8 Non-clinical Development; References; 4 Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity; Abstract; 1 Introduction; 2 Materials and Methods: Molecular Modeling Studies; 3 Identification of the Three-Dimensional Structural Features Responsible for the Antimalarial Activity; 3.1 First Series of New Synthetic Analogues of Plakortin.
505	8		_a6 A Growing Focus on Marine Natural Products7 Generating Natural Product Analogues; 7.1 Total Synthesis; 7.2 Semisynthesis; 7.3 Precursor-Directed Biosynthesis; 7.4 Mutasynthesis; 7.5 Combinatorial Biosynthesis; 7.6 Genochemetics: gene expression enabling synthetic diversification; 8 Concluding Remarks and Future Perspective; References; 6 New Target Sites for Treatment of Osteoporosis; Abstract; 1 Introduction; 2 Osteoporosis; 3 Bone Remodeling; 4 Drug Therapy/Treatment of Osteoporosis; 4.1 Hormone-Replacement Therapies; 4.2 Bisphosphonates; 4.3 New Therapies for Osteoporosis.
505	8		_aAcknowledgementsReferences; 2 Major Antimicrobial Representatives from Marine Sponges and/or Their Associated Bacteria; Abstract; 1 Introduction; 2 Antimicrobial Compounds from Marine Sponges; 2.1 Lipids; 2.2 Polyketides; 2.3 Steroids; 2.4 Terpenoids; 2.5 Alkaloids; 2.6 Peptides; 2.7 Miscellaneous Brominated Derivatives; 3 Antimicrobial Compounds from Sponge-Associated Bacteria; 4 Conclusions and Future Challenges; Bibliography; 3 Discovery and Development of Novel Drugs; Abstract; 1 Introduction; 2 Project Planning Phase; 3 Where to Start?; 4 Drug Discovery.
520	3		_aThis book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural productsℓ́ℓ chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating effects. Further, it employs molecular-biology-based approaches and advanced chemical techniques to obtain and to select candidate compounds for pre-clinical and clinical studies.
650		7	_aBiotecnología _2embne _0(OCoLC)fst01009475 _0 _9140931
700	1		_aMüller, Werner E. G., _eeditor literario _948424
700	1		_aSchröder, Heinz C., _eeditor literario
700	1		_aWang, Xiaohong, _cProfessor Dr., _eeditor literario _948425
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-51284-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017C
998			_b02/2018 _dz _e- _zSI
999			_c95471 _d95471 _x1