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020 _a3319493434
_q(electronic bk.)
020 _a9783319493435
_q(electronic bk.)
020 _z3319493426
020 _z9783319493428
_q(print)
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050 4 _aQP751
_b.L575 2017 EB
245 0 0 _aLipidomics of stem cells
_cAlice Pébay, Raymond C.B. Wong, editors.
264 1 _aCham, Switzerland
_bHumana Press
_c2017.
300 _a1 recurso en línea (xiii, 212 páginas)
_bilustraciones (algunas a color)
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 0 _aStem cell biology and regenerative medicine
500 _aIncluye índice
500 _aSpringerLink
_bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505 0 _aPreface; Contents; Contributors; Chapter 1: Lysophosphatidic Acid and€Sphingosine- 1-ƯPhosphate in€Pluripotent Stem Cells; 1.1 Introduction; 1.2 Lipid Homeostasis in€Stem Cell Biology; 1.3 LPA and€S1P Synthesis and€Degradation; 1.3.1 LPA; 1.3.2 S1P; 1.4 LPA and€S1P Signaling; 1.5 Role of€LPA and€S1P in€Pluripotent Stem Cells; 1.6 Discussion and€Conclusion; References; Chapter 2: Morphogenetic Sphingolipids in€Stem Cell Differentiation and€Embryo Development; 2.1 Ceramide and€Its Derivatives; 2.1.1 Ceramide and€Ceramide-Enriched Compartments; 2.1.1.1 Ceramide and€Cilia.
505 8 _a2.1.1.2 Ceramide and€Exosomes2.1.2 Sphingosine-1-Phosphate; 2.1.3 Ceramide-1-Phosphate; 2.1.4 Glycosphingolipids; 2.1.5 Sphingolipids in€Stem Cell Therapy and€Regenerative Medicine; 2.2 Other Lipids; 2.3 Concluding Remarks; References; Chapter 3: Autotaxin in€Stem Cell Biology and€Neurodevelopment; 3.1 Introduction; 3.2 A Historical Perspective; 3.3 Structure and€Functional Domains; 3.4 Functional Roles in€Stem Cell Biology; 3.4.1 Embryonic Stem Cells; 3.4.2 Tissue-Specific Stem Cells; 3.4.3 Cancer Stem Cells; 3.5 Functional Roles in€Neurodevelopment; 3.5.1 Neural Stem Cells and€Neurogenesis.
505 8 _a3.5.2 Oligodendrogenesis3.6 Conclusion; References; Chapter 4: Lysophosphatidic Acid (LPA) Signaling in€Neurogenesis; 4.1 Introduction; 4.2 LPA Structure, Distribution, and€Metabolism; 4.2.1 Structure; 4.2.2 Distribution; 4.2.3 Metabolism; 4.2.4 Catabolism; 4.3 Lysophosphatidic Acid Receptor Signaling and€Downstream Pathways; 4.3.1 LPA1; 4.3.2 LPA2; 4.3.3 LPA3; 4.3.4 LPA4; 4.3.5 LPA5; 4.3.6 LPA6; 4.4 Lysophosphatidic Acid Signaling in€Embryonic Corticogenesis and€Neurodevelopmental Disease; 4.4.1 Fetal Corticogenesis; 4.4.2 LPA Is a€Potent Neuromodulator.
505 8 _a4.4.3 LPA in€Mitogenesis and€Neurogenesis4.4.4 LPA in€NPC Survival and€Programmed Cell Death; 4.4.5 LPA and€NPC Migration; 4.5 LPA Signaling and€Neurodevelopmental Diseases; 4.5.1 Hypoxic Injury; 4.5.2 Schizophrenia; 4.5.3 Hemorrhagic Injury and€Hydrocephalus; 4.6 Conclusion; References; Chapter 5: Fate Through Fat: Neutral Lipids as€Regulators of€Neural Stem Cells; 5.1 Neural Stem Cells and€Adult Neurogenesis; 5.1.1 NSC Niches: Form and€Function; 5.1.1.1 Subventricular Zone; 5.1.1.2 Dentate Gyrus; 5.1.2 Heterogeneity Within the€NSC Continuum; 5.1.3 Human Neurogenesis.
505 8 _a5.2 Neutral Lipid Metabolism in€the€Adult Brain5.2.1 Fatty Acids; 5.2.2 Triacylglycerides; 5.2.3 Lipid Droplets; 5.2.4 Apolipoproteins; 5.3 Neutral Lipids Are Physiological Regulators of€Adult€NSCs; 5.3.1 Neutral Lipid Carriers Are Required for€NSC Maintenance and€Neurogenesis; 5.3.1.1 FABPs; 5.3.1.2 ApoE; 5.3.2 Fatty Acid Metabolism Is Required for€Proliferation of€NSCs; 5.3.3 Distinct Effects of€Fatty Acid Classes on€NSCs and€Neurogenesis; 5.3.3.1 Polyunsaturated Fatty Acids (PUFAs); 5.3.3.2 Saturated Fatty Acids (SFAs); 5.3.3.3 Monounsaturated Fatty Acids (MUFAs).
520 3 _aThis book combines the current knowledge on the role of lipids in stem cell pluripotency and differentiation. It showcases various approaches to the study of lipids and focuses on various types of stem cells and specific lipids driving maintenance or differentiation. The volume includes chapters reviewing roles of specific lipids in pluripotency, neurogenesis and exocytosis as well as in cancer stem cells. Examples of different classes of lipidsℓ́ℓsuch as sphingolipids, lysophospholipids, cannabinoids and neutral lipidsℓ́ℓare described and illustrate the vast biological effects of this class of molecules. The international contributors are all recognized experts in their respective fields. Covering the various aspects of the topic, Lipidomics of Stem Cells provides an up-to-date snapshotℓ́ℓunique among the literatureℓ́ℓof where the lipid world is in terms of understanding the roles of lipids in stem cell biology. It provides an essential reference for stem cell biologists, lipid biologists, development biologists, students, academics and clinicians in related areas.
650 7 _aLípidos
_2embne
_0(OCoLC)fst00999367
_0
_9142933
700 1 _aPébay, Alice,
_eeditor literario
700 1 _aWong, Raymond C. B.,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-49343-5
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988 _aEBOOK, asignarmaterias, EBSPRINGER_2017C
998 _b02/2018
_dz
_e-
_zSI
999 _c95466
_d95466
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