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008			170217s2017 sz ob 000 0 eng d
020			_a3319504134 _q(electronic bk.)
020			_a9783319504131 _q(electronic bk.)
020			_z3319504118
020			_z9783319504117
035			_a(OCoLC)972900340 _z(OCoLC)973126288 _z(OCoLC)973304824 _z(OCoLC)973383127 _z(OCoLC)973503037 _z(OCoLC)981772228 _z(OCoLC)1005810714 _z(OCoLC)1011849391
040			_aN$T _cN$T _dN$T _dIDEBK _dYDX _dGW5XE _dOCLCF _dNJR _dUAB _dMERUC _dCOO _dSTF _dOCLCO _dISM _dOCLCO _dIOG _dAZU _dVT2 _dUPM _dOCLCO _dMERER _dESU _dZ5A _dJBG _dIAD _dICW _dICN _dOCLCQ _dOCLCO _dOTZ _dOCLCQ _dOCLCO _dJG0 _dOCLCO _dU3W _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aQH442 _b.D574 2017 EB
245	0	0	_aDirected enzyme evolution : _badvances and applications _cMiguel Alcalde, editor.
264		1	_aCham, Switzerland _bSpringer _c[2017]
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas
505	0		_a1. Directed evolution for Opsin Engineering (Prof. Frances H. Arnold, Caltech, USA) -- 2. Directed evolution for enzyme enantio-selectivity (Prof. Manfred T. Reetz, Max-Planck-Institut für Kohlenforschung, Germany) -- 3. Directed evolution for fuels and chemicals (Prof. Huimin Zhao, University of Urbana-Champaign, Illinois, USA) -- 4. Directed evolution for cancer biopharmaceuticals (Prof. Dane Wittrup, MIT, USA) -- 5. Directed evolution of the ligninolytic consortium (Prof. Miguel Alcalde, Institute of Catalysis, CSIC, Madrid, Spain) -- 6. Directed evolution for engineering of metabolic pathways (Prof. Claudia Schmidt-Dannert, University of Minnesota, USA) -- 7. Directed evolution and metagenomics (Prof. Kenneth N. Timmis, Technische Universität Braunschweig, Germany) -- 8. Directed evolution and protein evolvability (Prof. Jesse Bloom, Fred Hutchinson Cancer Research Center, Seattle, USA) -- 9. Directed evolution for understanding natural evolution (Prof. Dan S. Tawfik, Weizmann Institute of Science, Rehovot, Israel) -- 10. Diversity methods for directed evolution (Prof. Ullrich Schwaneberg, RWTH-Aachen University, Germany) -- 11. Ancestral enzymes, evolution and resurrection (Prof. Jose Manuel Sanchez Ruiz, Universidad de Granada, Spain) -- 12. Directed evolution and computational protein algorithms (Prof. Victor Guallar, Barcelona Supercomputing Center, Spain).
520	3		_aThis book focuses on some of the most significant advances in enzyme engineering that have been achieved through directed evolution and hybrid approaches. On the 25th anniversary of the discovery of directed evolution, this volume is a tribute to the pioneers of this thrilling research field, and at the same time provides a comprehensive overview of current research and the state of the art. Directed molecular evolution has become the most reliable and robust method to tailor enzymes, metabolic pathways or even whole microorganisms with improved traits. By mirroring the Darwinian algorithm of natural selection on a laboratory scale, new biomolecules of invaluable biotechnological interest can now be engineered in a manner that surpasses the boundaries of nature. The volume is divided into two sections, the first of which provides an update on recent successful cases of enzyme ensembles from different areas of the biotechnological spectrum, including tryptophan synthases, unspecific peroxygenases, phytases, therapeutic enzymes, stereoselective enzymes and CO2-fixing enzymes. This section also provides information on the directed evolution of whole cells. The second section of the book summarizes a variety of the most applicable methods for library creation, together with the future trends aimed at bringing together directed evolution and in silico/computational enzyme design and ancestral resurrection.
650		7	_aEnzimas _xBiotechnology. _2embne _0(OCoLC)fst00913608 _0 _9138640
700	1		_aAlcalde, Miguel, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-50413-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017B
998			_b02/2018 _dz _e- _zSI
999			_c95404 _d95404 _x1