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008			170211s2017 xx o 000 0 eng d
020			_a3319461893
020			_a9783319461892
020			_z3319461877
020			_z9783319461878
035			_a(OCoLC)972290204 _z(OCoLC)971908775 _z(OCoLC)972126868 _z(OCoLC)972238923 _z(OCoLC)972460270 _z(OCoLC)981820302 _z(OCoLC)982174280 _z(OCoLC)1005794434 _z(OCoLC)1012056573
040			_aEBLCP _cEBLCP _dYDX _dUAB _dIOG _dAZU _dUPM _dOCLCF _dCOO _dESU _dJBG _dIAD _dICW _dICN _dOTZ _dOCLCQ _dU3W _dES-MaUEC _bspa
050		4	_aRA1242.N58 _b2017 EB
100	1		_aBryan, Nathan S. _eautor
245	1	0	_aNitrite and Nitrate in Human Health and Disease.
250			_a2nd ed.
264		1	_aCham _bSpringer International Publishing _c2017
300			_a1 recurso en línea (367 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	0		_aNutrition and Health
505	0		_aForeword; Preface; Series Editor Page; Part I: Biochemistry, Molecular Biology, Metabolism and Physiology; Part II: Food and Environmental Exposures to Nitrite; Part III: Nitrite and Nitrate in Therapeutics and Disease; Conclusions; About the Series Editors; About Volume Editors; Contents; Contributors; Part I: Biochemistry, Molecular Biology, Metabolism and Physiology; Chapter 1: Introduction; Introduction; Two Redundant Pathways for Endogenous NO Synthesis; Salivary Nitrate Concentration and Reduction; Salivary Nitrite Reduction to NO.
505	8		_aEnterosalivary Circulation of Nitrate/Nitrite/NO Urinary Nitrate Excretion; Conclusion; References; Chapter 3: Nitrate-Reducing Oral Bacteria: Linking Oral and Systemic Health; Introduction; Nitrate-Nitrite-Nitric Oxide Pathway; Nitrite-Based Signaling; Bacterial Nitrate Reduction; How to Determine the Presence or Absence of Nitrate-Reducing Bacteria; Restoring and Repopulation of Nitrate-Reducing Bacteria; Conclusion; References; Chapter 4: Epigenetics and the Regulation of Nitric Oxide; Introduction; Epigenetic Tags; DNA Methylation; Histone Modification; Histone Acetylation.
505	8		_aHistone MethylationHistone Lysine Methylation; Histone Arginine Methylation; Epigenetic Regulation of NOS Genes; NOS1 Regulation and Epigenetic Crosstalk; NOS2A Regulation and Epigenetic Crosstalk; NOS3 Regulation and Epigenetic Crosstalk; Overview of NO Regulation of HDAC; Overview of the Epigenetic Regulation of NO Production; Conclusion; References; Chapter 5: The Mitochondrion: A Physiological Target of Nitrite; Introduction; Mitochondrial Function: ATP Generation and Beyond; Nitrite Formation and Reduction; Nitrite Reduction by Mitochondria.
505	8		_aMitochondria as a Physiological Target of Nitrite S-Nitrosation of Complex I to Attenuate Ischemia/Reperfusion Injury; Heme Nitrosylation of Complex IV: Conservation of Oxygen and Short-Term Hibernation; Nitrite-Dependent Regulation of Mitochondrial Ion Channels: Putative Targets in I/R; Downregulation of Adenine Nucleotide Translocase and Uncoupling Protein 3: Enhanced Exercise Efficiency; Nitrite Regulation of Mitochondrial Dynamics and Number; Nitrite Stimulates Mitochondrial Biogenesis; Nitrite Modulates Mitochondrial Dynamics to Mediate Preconditioning; Conclusions; References.
505	8		_aSafely Harnessing the Therapeutic Effects of Nitrite and Nitrate Conclusion; References; Chapter 2: From Atmospheric Nitrogen to Bioactive Nitrogen Oxides; Introduction; Nitrate, Agriculture, and Economics; Nitrogen Fixation; Microbial Dinitrogen Fixations; Haber-Bosch; Fossil Fuel Combustion; Atmospheric Nitrogen Fixation by Lightning; Nitrate Assimilation in Plants and Bacteria; Nitrification; Denitrification; Dissimilatory Reduction of Nitrate to Ammonia; Anammox; Nitrogen Balance in Mammals; l-Arginine Nitric Oxide Synthase Pathway; Dietary Sources of Nitrate and Nitrite.
520	3		_aThis fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references. The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function. Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.
650		7	_aBioquímica clínica _2embne _0(OCoLC)fst00864329 _0 _9149316
700	1		_aLoscalzo, Joseph _d1951- _983290
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-46189-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _e- _zSI
999			_c95365 _d95365 _x1