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008			170211s2017 xx o 000 0 eng d
020			_a3319504096
020			_a9783319504094
020			_z3319504088
020			_z9783319504087
035			_a(OCoLC)972289536 _z(OCoLC)971542228 _z(OCoLC)971600240 _z(OCoLC)971956168 _z(OCoLC)972103754 _z(OCoLC)972205276 _z(OCoLC)981813826 _z(OCoLC)982182099
040			_aEBLCP _cEBLCP _dYDX _dIDEBK _dN$T _dGW5XE _dOCLCF _dNJR _dDKU _dUAB _dIOG _dAZU _dVT2 _dUPM _dCOO _dESU _dZ5A _dOCLCO _dJBG _dIAD _dOCLCO _dGZM _dICW _dOCLCO _dICN _dILO _dOCLCO _dOCLCQ _dMERER _dOCLCO _dOCLCQ _dOCLCO _dJG0 _dOCLCO _dU3W _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aRC123.C3 _b2017 EB
100	1		_aPrasad, Rajendra.
245	1	0	_aCandida albicans.
250			_a2nd ed.
264		1	_aCham _bSpringer International Publishing _c2017
300			_a1 recurso en línea (552 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
500			_a7.5 Future Opportunities.
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505	0		_aContributors; 1 Introduction; Acknowledgements; References; 2 Current Trends in Candidiasis; Abstract; 2.1 Introduction; 2.2 Epidemiology; 2.3 Emergence of Candida auris; 2.4 Recent Trends in Anatomical Distribution of Candidal Infections; 2.4.1 Intra-Abdominal Candidiasis (IAC); 2.4.2 Hepatosplenic Disease; 2.4.3 Neonatal Candidiasis; 2.4.4 Genitourinary Candidiasis; 2.4.5 Catheter-Associated Disseminated Candidiasis; 2.5 Host Defense Against Candidiasis; 2.6 Diagnosis; 2.6.1 Use of Cultures for Diagnosis of Systemic Candidiasis; 2.6.2 Antigen and Antibody Detection.
505	8		_a2.6.3 [beta]-D-Glucan Detection2.6.4 Polymerase Chain Reaction; 2.7 Summary; References; 3 Invasive Candidiasis in the Southeast-Asian Region; Abstract; 3.1 Introduction; 3.2 Disease Spectrum; 3.3 Epidemiology; 3.3.1 Prevalence; 3.3.2 Risk Factors; 3.3.3 Spectrum of Candida Species; 3.4 Antifungal Resistance; 3.5 Diagnostic Challenges; 3.6 Management; 3.7 Conclusion; References; 4 Morphogenesis in C. albicans; Abstract; 4.1 C. albicans Morphologies; 4.2 Relationship Between C. albicans Morphology and Virulence; 4.3 Mechanics of C. albicans Hyphal Growth.
505	8		_a4.4 Control of C. albicans Hyphal Growth by the Cell Cycle4.5 Regulation of the C. albicans Morphological Transition by Host Environmental Cues; 4.6 Genome-Wide Analyses of the C. albicans Morphological Transition; 4.7 C. albicans Morphology as a Target for Novel Therapeutic Strategies; Acknowledgements; References; 5 Candida albicans Biofilms; Abstract; 5.1 Introduction; 5.2 Characteristics of C. albicans Biofilm; 5.3 Genetic Regulation of C. albicans Biofilm Formation; 5.3.1 Adherence; 5.3.2 Hyphal Development; 5.3.3 Biofilm Dispersal; 5.3.4 Extracellular Matrix (ECM).
505	8		_a5.4 Future PerspectivesReferences; 6 Candida Biofilm Tolerance: Comparison of Planktonic and Biofilm Resistance Mechanisms; Abstract; 6.1 Introduction; 6.2 Overview of Antifungal Drug Classes and Planktonic Candida Resistance Mechanisms; 6.2.1 Triazoles; 6.2.2 Polyenes; 6.2.3 Echinocandins; 6.2.4 5-FC/Flucytosine; 6.3 Candida Biofilm Resistance Mechanisms; 6.3.1 Role of Efflux Pumps; 6.3.2 Influence of Sterol Synthesis; 6.3.3 Impact of Cell Density and Quorum Sensing; 6.3.4 Contribution of Biofilm Extracellular Matrix; 6.3.5 Presence of Persister Cells; 6.4 Conclusion.
505	8		_a7 In Vivo Candida Device Biofilm ModelsAbstract; 7.1 Significance of Fungal Biofilms in Infection; 7.2 Fungal Biofilm Traits; 7.2.1 Structure and Composition; 7.2.2 Tolerance to Antifungals; 7.2.3 Immune Resistance; 7.3 Host Factors Influencing Fungal Biofilms; 7.3.1 Flow Conditions; 7.3.2 Substrates and Conditioning; 7.3.3 Nutrient Composition; 7.3.4 Host Immune Components; 7.4 In Vivo Models of Fungal Biofilms and Drug Discovery; 7.4.1 Vascular Catheter Model; 7.4.2 Denture Model; 7.4.3 Subcutaneous Implant Model; 7.4.4 Urinary Catheter Model; 7.4.5 Mucosal Candidiasis Models.
520	3		_aThis book on Candida albicans and similar pathogens provides a timely overview of the groundbreaking discoveries made in the areas of drug resistance, hostℓ́ℓpathogen interactions, virulence, host immune system modulation, etc., in the last two decades. This comprehensive 2nd Edition includes chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal agents, multidrug transporters, virulence mechanisms in Candida albicans, hostℓ́ℓpathogen interactions, the cell wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and last but not the least host-immune responses. As such, it offers an ideal reference guide for mycologists, researchers, pharmacists, clinicians, and undergraduate students engaged or interested in fungal research. It will also benefit clinicians, who are required to keep abreast of the current state of research on antifungal drug resistance and antifungal development.
650		7	_aCandida albicans. _2fast _0(OCoLC)fst00845627 _9143572 _0comprobar BNE19901043705
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-50409-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017B
998			_b02/2018 _dz _e- _zSI
999			_c95363 _d95363 _x1