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006			m o d
007			cr cnu|||unuuu
008			170210s2017 sz o 001 0 eng d
020			_a3319488228
020			_a3319488244 _q(electronic bk.)
020			_a9783319488226
020			_a9783319488240 _q(electronic bk.)
020			_z9783319488226 _q(print)
035			_a(OCoLC)972092273 _z(OCoLC)981890056 _z(OCoLC)992889991 _z(OCoLC)1005793147 _z(OCoLC)1011849390
040			_aN$T _cN$T _dYDX _dIDEBK _dGW5XE _dN$T _dOCLCF _dNJR _dCOO _dAZU _dUPM _dMERER _dZ5A _dOCLCQ _dVT2 _dUAB _dES-MaUEC _bspa
050		4	_aQP552.N43 _bT446 2017 EB
245	0	4	_aThe neuropilins : _brole and function in health and disease _cGera Neufeld, Ofra Kessler, editors.
264		1	_aCham, Switzerland _bSpringer _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
500			_aIncluye índice
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505	0		_aMolecular mechanisms of neuropilin mediated VEGF and other growth factors induced signal transduction -- 1. The role of the neuropilins in VEGF signal transduction -- 2. The role of neuropilins in signaling induced by non-VEGF growth factors -- 3. Structure function studies of neuropilins in the context of their interaction with VEGF and VEGF receptors. Semaphorin signaling -- 1. Stucture function studies of functional class-3 semaphorin receptors -- 2. Control of cytoskeletal organization by class-3 semaphorins -- 3. Control of cell adhesion by class-3 semaphorin activated signaling -- Short Topics. 4. Gating of plexin-D1 function by neuropilin -- 5. Interaction of neuropilins with cell adhesion receptors and its effect on class-3 semaphorin signaling. Neuropilins as a regulators of developmental angiogenesis and lymphangiogenesis -- 1. Role of neuropilins in the regulation of developmental angiogenesis -- 2. The role of the neuropilins in the development of the lymphatic system -- Short Topics -- 3. The role of the neuropilins in the determination of artery/vein identity -- 4. Neuropilin-1 mediated differentiation of multipotent progenitor cells to endothelial cells -- 5. Role of neuropilin-1 and Phactr-1 in tube formation. Neuropilins as regulators of immune responses 1. Immunological functions of the neuropilins -- Short Topics. 2. Stability and function of regulatory T cells is maintained by a neuropilin-1- semaphorin-4a axis -- 3. Neuropilin 1 guides regulatory T cells into VEGF-producing melanomas. The role of neuropilins in tumor progression 1. Neuropilins as regulators of tumor progression -- Short Topics. 2. Neuropilin-1 on cancer stem cells -- 3. Sema3A induced neuropilin-1 mediated recruitment of endothelial progenitor cells to tumors -- 4. Neuropilins mediate recruitment of macrophages to hypoxic regions in tumors. Nervous system. 1. The role of neuropilins and their semaphorin and VEGF ligands in the development and function of the nervous system -- Short Topics. 2. Neuropilins and neurotrophins in central nervous system development -- The role of neuropilins in retinal development and retinal diseases. 1. The role of the neuropilins in the development of the retina and retinal diseases.-
520	3		_aThis book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases. The two neuropilin genes encode scaffold receptors that can bind several different ligands, and also associate with many other receptors and modify their activity. Further, it has been confirmed that they play important roles in the shaping of major organs and tissues such as the nervous system and the vascular system, and that they can modulate immune responses. The book offers a helpful guide for biomedical researchers and all scientists active in the neurosciences, vascular and molecular biology, as well as developmental biology and immunology.
650		7	_aProteínas _2embne _0(OCoLC)fst01036478 _0 _9139861
700	1		_aKessler, Ofra, _eeditor literario
700	1		_aNeufeld, Gera, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-48824-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017B
998			_b02/2018 _dz _e- _zSI
999			_c95357 _d95357 _x1