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020			_a3319505203 _q(electronic bk.)
020			_a9783319505206 _q(electronic bk.)
020			_z331950519X _q(print)
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050		4	_aQR201.H44 _bM654 2017 EB
245	0	0	_aMolecular pathogenesis and signal transduction by helicobacter pylori _cNicole Tegtmeyer, Steffen Backert, editors.
264		1	_aCham, Switzerland _bSpringer _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	0		_aCurrent topics in microbiology and immunology _vvolume 400
500			_aSpringerLink
505	0		_aForeword; Preface; Contents; Abbreviations; 1 The Human Stomach in Health and Disease: Infection Strategies by Helicobacter pylori; Abstract; 1 Introduction; 2 H. pylori Infection and Strategies of Persistence; 3 H. pylori Infection in Health and Disease; 3.1 Gastritis; 3.2 Peptic Ulcer Disease; 3.3 Gastric Adenocarcinoma; 3.4 MALT Lymphoma; 4 H. pylori Virulence Factors and their Association with Disease; 4.1 The cag Pathogenicity Island; 4.2 Vacuolating Cytotoxin (VacA); 4.3 DupA and tfs4; 4.4 NapA; 4.5 Adhesins; 5 Environmental Factors and their Association with Disease.
505	8		_a2.3 Inhibition of Antimicrobial Peptides3 Immune Tolerance Driven by H. pylori Interaction with Dendritic Cells; 4 Manipulation and Inhibition of Effector T Cell Responses; 5 Bacterial Plasticity and Immune Evasion; 6 Concluding Remarks; References; 4 Recent Advances in Helicobacter pylori Replication: Possible Implications in Adaptation to a Pathogenic Lifestyle and Perspectives for Drug Design; Abstract; 1 Introduction; 2 Chromosome Replication in Bacteria; 3 Chromosome Replication in Helicobacter pylori; 3.1 Initiation; 3.2 Elongation; 3.3 Termination; 3.4 Segregation.
505	8		_a4 Regulation of H. pylori Chromosome Replication5 Plasmid Replication in Bacteria; 6 Plasmid Replication in Helicobacter pylori; 7 Beyond the Replication Flowchart; 8 Concluding Remarks; Acknowledgements; References; 5 The Helicobacter pylori Methylome: Roles in Gene Regulation and Virulence; Abstract; 1 Introduction; 2 The Restriction-Modification (R-M) Systems and Their Diversity in H. pylori; 3 The H. pylori Methylomes; 4 Roles of H. pylori Methyltransferases (Mtases) in Gene Regulation; 4.1 Gene Regulation by E. coli Deoxyadenosine Methyltransferase (Dam) and Its Homologues.
505	8		_a4.2 NO-Mediated H. pylori Carcinogenesis4.3 NOS2 Polymorphisms; 5 The Host and Bacteria Coevolution: The Crystal Ball of H. pylori Pathogenesis?; 6 Concluding Remarks; References; 3 Immune Evasion Strategies and Persistence of Helicobacter pylori; Abstract; 1 Introduction; 2 Innate Immune Evasion Strategies of H. pylori; 2.1 Evasion and Manipulation of Pattern Recognition Receptors; 2.1.1 Evasion of TLR Recognition and Manipulation of TLR-Mediated Signaling; 2.1.2 Inhibition of CLR-Mediated Signaling; 2.2 Inhibition of Phagocytosis and Killing by Reactive Oxygen Species and Nitric Oxide.
505	8		_a6 Treatment of H. pylori and Prospects for a Vaccine7 Concluding Remarks; Acknowledgements; References; 2 Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases; Abstract; 1 Helicobacter pylori: From Infection to Diseases; 2 The Chemokine CXCL8; 2.1 Induction of CXCL8 by H. pylori; 2.2 CXCL8 Gene Polymorphisms; 3 Induction and Role of ROS; 3.1 ROS During H. pylori Infection; 3.2 Expression and Role of NOX1; 3.3 Expression and Role of NOX2; 3.4 Expression and Role of SMOX; 3.5 Epigenetic Regulation of SMOX; 4 Nitrosative Stress; 4.1 H. pylori Infection and NOS2.
520	3		_aThis volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases. Written by internationally respected scientists, this book will appeal to clinicians, researchers and advanced students alike.
588	0		_aVersión impresa
988			_aEBOOK, EBSPRINGER_2017B
650		7	_2embne _9150368 _aInfecciones por Helicobacter pylori
700	1		_aBackert, Steffen, _eeditor literario _999785
700	1		_aTegtmeyer, Nicole, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-50520-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI