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020			_a3319475185 _q(electronic bk.)
020			_a9783319475172
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035			_a(OCoLC)970041798 _z(OCoLC)970385822 _z(OCoLC)970612995 _z(OCoLC)970788925 _z(OCoLC)971044749 _z(OCoLC)971069835 _z(OCoLC)974651258 _z(OCoLC)981034139 _z(OCoLC)981776572 _z(OCoLC)986455399 _z(OCoLC)988086572 _z(OCoLC)990548987 _z(OCoLC)995589419 _z(OCoLC)1003201208 _z(OCoLC)1004972566 _z(OCoLC)1011119291 _z(OCoLC)1011847479 _z(OCoLC)1013729818 _z(OCoLC)1016965817
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050		4	_aRC606.6 _b2017 EB
245	0	4	_aThe CAPRISA clinical trials : _bHIV treatment and prevention _cQuarraisha Abdool Karim, Salim S. Abdool Karim, Cheryl Baxter, editors.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPart I. Introduction -- Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda -- CAPRISA: Establishing A Research Center to Undertake HIV Clinical Trials -- Overview of Clinical Trials -- Part II. CAPRISA Clinical Trials for HIV and HSV-2 Prevention -- Antiretrovirals for HIV Prevention -- Rolling out of tenofovir gel in family planning clinics: the CAPRISA 008 implementation trial -- Conditional cash transfers to reduce HIV risk in young women: the CAPRISA 007 cluster randomised control trial -- HIV vaccine and passive immunity trials -- Part III: CAPRISA Clinical Trials for HIV?TB Treatment -- CAPRISA 003: Timing of antiretroviral initiation in HIV-TB co-infected patients -- The SAPiT Trial -- Scaling up TB-HIV integration in public health clinics: translating research findings into practice -- Part IV: Experiences and lessons learnt from clinical trials in CAPRISA -- Lessons from the Acute Infection Study: from Bench to Bedside -- Understanding sexual HIV transmission in women by focusing on the genital mucosa -- Part V: Essential support activities for the conduct of clinical trials -- Good practices in conducting clinical trials: Good Participatory Practice, Good Pharmacy Practice and Good Laboratory Practice -- Grants Management -- Taking science to the people: communication and media strategies for clinical trials -- Looking ahead: What Does the Future Hold for CAPRISA? -- Appendix -- Index.
520	3		_aSince its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA?s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. Comprised of 5 sections, the book details the following: HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV. CAPRISA?s clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies. CAPRISA?s research on the treatment of HIV and TB co-infection. A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology. Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials. The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials? their creation, conduct and impact.
650		7	_aEnsayos clínicos _2embne _0(OCoLC)fst00864429 _0 _9144524
700	1		_aAbdool Karim, Q. _q(Quarraisha), _eeditor literario
700	1		_aBaxter, Cheryl, _eeditor literario
700	1		_aKarim, Salim S. Abdool, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-47518-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _e- _zSI
999			_c95266 _d95266 _x1