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008			170118s2017 ja ob 000 0 eng d
020			_a4431560033 _q(electronic bk.)
020			_a9784431560036 _q(electronic bk.)
020			_z4431560017
020			_z9784431560012 _q(print)
035			_a(OCoLC)968926397 _z(OCoLC)969419144 _z(OCoLC)974650925 _z(OCoLC)981844081 _z(OCoLC)1005780132 _z(OCoLC)1012016545
040			_aN$T _cN$T _dEBLCP _dGW5XE _dYDX _dN$T _dOCLCF _dIDEBK _dUAB _dNJR _dUPM _dOCLCO _dIOG _dOCLCO _dOCLCA _dMERER _dESU _dZ5A _dOCLCO _dOCLCQ _dOCLCO _dJBG _dIAD _dOCLCO _dICW _dOCLCO _dICN _dOCLCQ _dOCLCO _dOTZ _dOCLCQ _dVT2 _dOCLCO _dOCLCQ _dU3W _dOCLCO _dOCLCQ _dOCLCO _dES-MaUEC _bspa
050		4	_aRC641.7.P37 _b2017 EB
245	0	0	_aParoxysmal nocturnal hemoglobinuria : _bfrom bench to bedside _cYuzuru Kanakura, Taroh Kinashita, Jun-ichi Nishimura, editors.
264		1	_aTokyo, Japan _bSpringer International Publishing _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
504			_aIncluye referencias bibliográficas
505	0		_a1 A History of Research of PNH: Defining a Disease -- Part I Basic Sciences in PNH -- 2 Synthesis, genetics and congenital diseases of GPI-anchored proteins -- 3 Animal models of paroxysmal nocturnal hemoglobinuria -- 4 Complement and PNH -- Part II Clinical Sciences in PNH -- 5 Epidemiology in PNH: The PNH Global Registry -- 6 Epidemiology in PNH; Clinical Epidemiological Studies in Korea -- 7 Hemolysis in PNH; Depletion of nitric oxide -- 8 Bone Marrow Failure in PNH -- 9 Thrombophilia in PNH -- 10 Diagnosis and Classification of PNH -- 11 Clinical significance of a small population of glycosyl phosphatidylinositol-anchored membrane proteins (GPI-APs)-deficient cells in the management of bone marrow failure -- 12 CLONAL ORIGIN AND CLONAL SELECTION IN PNH -- 13 Pathogenesis of clonal dominance in PNH: Selection mechanisms in PNH -- 14 Pathogenesis of Clonal Dominance in PNH; Growth Advantage in PNH -- 15 Clinical Management in PNH -- 16 CLINICAL EFFECTS OF ECULIZUMAB IN PNH -- 17 Clinical Effects of Eculizumab in PNH; Extravascular Hemolysis after Eculizumab Treatment -- 18 Clinical Effects of Eculizumab in PNH; Poor-Responders to Eculizumab -- 19 Hematopoietic Stem Cell Transplantation in PNH -- 20 Future strategies of complement inhibition in paroxysmal nocturnal hemoglobinuria -- 21 Pregnancy in paroxysmal nocturnal hemoglobinuria.
520	3		_aThis volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book, Paroxysmal Nocturnal Hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure.
650		7	_aAnemia _2embne _0(OCoLC)fst01053903 _0 _9138497
700	1		_aKanakura, Yuzuru, _d1953- _eeditor literario
700	1		_aKinoshita, T. _q(Taroh), _d1951- _eeditor literario
700	1		_aNishimura, Jun-ichi, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-4-431-56003-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _e- _zSI
999			_c95228 _d95228 _x1