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006			m o d
007			cr cnu|||unuuu
008			170110s2017 sz o 001 0 eng d
020			_a3319483447 _q(electronic bk.)
020			_a9783319483443 _q(electronic bk.)
020			_z3319483439
020			_z9783319483436
035			_a(OCoLC)967982017 _z(OCoLC)968646164 _z(OCoLC)974650093 _z(OCoLC)981821054 _z(OCoLC)1005781279 _z(OCoLC)1011847430
040			_aN$T _cN$T _dIDEBK _dGW5XE _dYDX _dN$T _dEBLCP _dN$T _dOCLCF _dUAB _dCOO _dNJR _dDKU _dUPM _dMERUC _dIOG _dMERER _dESU _dOCLCQ _dJBG _dIAD _dICW _dICN _dOTZ _dOCLCQ _dVT2 _dU3W _dES-MaUEC _bspa
050		4	_aQH452.3 _bH863 2017 EB
245	0	0	_aHuman retrotransposons in health and disease _cGael Cristofari, editor.
264		1	_aCham _bSpringer _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
500			_aIncluye índice
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505	0		_aRetrotransposons and the Mammalian Germline -- L1 regulation in Mouse and Human Germ Cells -- Retrotransposon Contribution to Genomic Plasticity -- The Mobilization of Processed Transcripts in Germline and Somatic Tissues -- Neuronal Genome Plasticity: Retrotransposons, Environment and Disease -- Activity of Retrotransposons in Stem Cells and Differentiated Cells -- Environment, Cellular Signaling and L1 activity -- Retrotransposon-derived Regulatory Regions and Transcripts in Stemness -- Roles of Endogenous Retrovirus-encoded Syncytins in Human Placentation -- Alu-Alu Recombinations in Genetic Diseases -- Retrotransposon-driven Transcription and Cancer -- LINE-1 retrotransposons as Neoplastic Biomarkers -- Contribution of Retrotransposable Elements to Aging.
520	3		_aThis unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80ℓ́ℓs. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.
650		7	_aADN _2embne _0(OCoLC)fst01155415 _0 _9140806
700	1		_aCristofari, Gael, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-48344-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017B
998			_b02/2018 _dz _e- _zSI
999			_c95194 _d95194 _x1