000			04152cam a2200409Mi 4500
001			95161
003			ES-MaUEC
005			20230102112650.0
006			m o d
007			cr |||||||||||
008			161223t20172017sz a ob 001 0 eng d
020			_a3319426303
020			_a331942632X _q(electronic bk.)
020			_a9783319426303
020			_a9783319426327 _q(electronic bk.)
020			_z9783319426303 _q(print)
035			_a(OCoLC)967844931 _z(OCoLC)974651698 _z(OCoLC)981112637 _z(OCoLC)1005794709 _z(OCoLC)1012044395
040			_aIDEBK _cIDEBK _dGW5XE _dYDX _dAZU _dOCLCF _dUAB _dCOO _dUPM _dVT2 _dIOG _dESU _dJBG _dIAD _dICW _dICN _dILO _dOTZ _dOCLCQ _dIDEBK _dU3W _dES-MaUEC _bspa
050		4	_aRC280.A4 _b2017 EB
245	0	0	_aGastrointestinal stromal tumors : _bbench to bedside _cCharles R. Scoggins, Chandrajit P. Raut, John T. Mullen, editors.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
264		4	_c2017
300			_a1 recurso en línea (242 páginas) _bilustraciones
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aEtiology/Epidemiology -- Pathology -- Molecular Genetics of GIST -- Pediatric GIST/Inheritable Disease -- Natural History -- Radiographic Imaging -- Endoscopic Evaluation -- Prognostic Factors for Localized Disease -- Management of Localized GIST: Non-Surgical Approaches-Surveillance and Endoscopic Resection -- Surgery for Localized GIST -- Minimally Invasive Surgery for GIST -- Neoadjuvant Rx and Surgical Consolidation -- Imatinib -- Management of Locally Advanced GIST -- Prognostic Factors for Advanced GIST -- Concepts of Targeted Therapy Management, Dose Escalation, Tailoring Therapy Based on Specific Mutations, Second Line Therapy -- Surgical Debulking of Metastatic GIST -- Liver Resection/Ablation of Metastatic GIST -- Palliative Care.
520	3		_aThis textbook provides a comprehensive, state of the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in GIST. The book reviews new data about risk factors for the disease, profiles the new staging system for GIST, highlights our current understanding of genetic mutations that lead to GIST, and provides new perspectives about imaging of GIST tumors. For localized disease, a greater appreciation of organ-sparing approaches and the importance of preservation of gastrointestinal function is discussed in detail, and advances in surgical techniques are highlighted, including minimally invasive surgery. For metastatic disease, the molecular biology of GIST is reviewed in a detailed and understandable manner, including the data that has fostered novel targeted approaches that have revolutionized management. Several landmark trials have been published in the last few years and are placed in context with respect to current management. Integration of surgery and systemic therapy through consolidative approaches has yielded provocative data that promises to further advance the field, and major advances in this domain are also discussed. Gastrointestinal Stromal Tumors: Bench to Bedside will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.
650		7	_aGastroenterología _2embne _0(OCoLC)fst01741222 _0 _9141308
700	1		_aMullen, John T., _eeditor literario
700	1		_aRaut, Chandrajit P., _eeditor literario
700	1		_aScoggins, Charles R., _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-42632-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _e- _zSI
999			_c95161 _d95161 _x1