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008			161202s2017 sz a ob 001 0 eng d
020			_a3319421697 _q(electronic book)
020			_a9783319421698 _q(electronic book)
020			_z3319421670
020			_z9783319421674
035			_a(OCoLC)966254664 _z(OCoLC)974650818 _z(OCoLC)981112387 _z(OCoLC)1005794682
040			_aYDX _cYDX _dGW5XE _dOCLCO _dOCLCA _dIDEBK _dAZU _dYDX _dUAB _dOCLCO _dCOO _dMERUC _dUPM _dOCLCO _dOCLCF _dOCLCO _dVT2 _dIOG _dMERER _dESU _dZ5A _dLIP _dJBG _dIAD _dICW _dICN _dOTZ _dOCLCQ _dOCLCO _dCNCGM _dU3W _dES-MaUEC _bspa
050		4	_aR857.N34 _bD475 2017 EB
245	0	0	_aDesign and applications of nanoparticles in biomedical imaging _cJeff W.M. Bulte, Michel M.J. Modo, editors
264		1	_aCham, Switzerland _bSpringer _c2017
300			_a1 recurso en línea (VIII, 469 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
500			_aSpringerLink
504			_aIncluye referencias bibliográficas e índice
505	0		_aPreface; Contents; Nanoparticles as a Technology Platform for Biomedical Imaging; 1 Origins of Nanoparticles in Biomedical Imaging; 2 The Emergence of a Synergy Between Therapeutics and Imaging; 3 An Outlook on Challenges and Future Opportunities; References; Basic Principles of In Vivo Distribution, Toxicity, and Degradation of Prospective Inorganic Nanoparticles for Imaging; 1 General Introduction; 1.1 Applying Inorganic Nanoparticles for Imaging; 1.2 Nanoparticles' Fate in a Nutshell; 1.3 The Nanoparticle-Protein Associates.
505	8		_a1.4 Nanoparticle Coating: The Essential But Transient Element in Particle Stabilization and Follow-Up1.5 Cellular "Conditioning" of Administered Nanoparticles and Its Impact on Imaging Outcomes; 1.6 Different Aspects of Biotransformation: Therapeutic Properties, Loss of Functionality, and Potential Toxicity; 1.7 Material-Specific Degradation Patterns of Inorganic Nanoparticles In Vivo and Over Time; 2 Iron Oxide Nanoparticles; 2.1 Role, Effect, and Fate of IONP Synthetic (Polymer) and Biological (Corona) Coating.
505	8		_a2.2 Cell Internalization of IONPs and Its Effects on Nanoparticles' Magnetic Properties2.3 Degradation and Recycling of IONPs; 2.4 In Vivo Toxicity of IONPs; 3 Quantum Dots; 3.1 Cellular Processing and Fate of QDots; 3.2 Skin: The Underemphasized Organ of Nanoparticle's Accumulation; 3.3 In Vivo Toxicity of QDs; 4 Silver Nanoparticles (Ag NPs); 4.1 Therapeutic Properties and In Vivo Behavior of Ag NPs; 4.2 Toxicity of Ag NPs; 5 Gold Nanoparticles (Au NPs); 5.1 Role, Effect, and Fate of Au NPs; 5.2 Cell Internalization of Au NPs.
505	8		_a5.3 Long-Lasting, But Not "Eternal": The In Vivo Biopersistence of Au NPs5.4 In Vivo Toxicity of Au NPs; 6 Conclusion; References; Imaging and Therapeutic Potential of Extracellular Vesicles; 1 Introduction; 2 EV Classification and Biogenesis; 3 EV Production; 4 EV Loading; 4.1 Loading the Parent Cell Before EV Release; 4.2 Loading During EV Production; 4.3 Direct Loading or Decoration of EVs; 5 EV Isolation; 6 Characterization; 7 Engineering Vesicles for Imaging: Biodistribution Investigation; 8 Engineering Vesicles for Therapy and Theranosis; 9 Conclusions; References.
505	8		_aMagnetic Particle Imaging1 Unmet Biomedical Imaging Needs; 2 Introduction to Magnetic Particle Imaging; 2.1 MPI Trade-Offs; 2.2 How MPI Works; 2.3 The Direct Feed-Through Challenge; 2.4 MPI Signal Is Independent of Depth; 2.5 MPI Sensitivity Is Linear, Robust, and Ideal; 2.6 MPI Resolution; 2.7 Prototype Preclinical MPI Scanners; 3 Clinical and Preclinical Applications of Magnetic Particle Imaging; 3.1 Long-Term MPI Tracking of Neural Progenitor Cells; 3.2 Dynamic, Systemic Stem Cell Tracking; 3.3 MPI Angiography Enabled by Advanced Image Reconstruction.
520	3		_aThis book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, US nanoparticles for imaging drug delivery, inorganic nanoparticles for targeted CT imaging, and quantum dots for optical imaging. This book serves as a valuable resource for the fundamental science of diagnostic nanoparticles and their interactions with biological targets, providing a practical handbook for improved detection of disease and its clinical implementation.
588	0		_aOnline resource; title from digital title page (viewed on December 13, 2016).
988			_aEBOOK, EBSPRINGER_2017B
650		7	_aNanotecnología _2embne _9158453
700	1		_aBulte, Jeff W. M., _eeditor literario
700	1		_aModo, Michel Mathias Jeannot Joseph, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-42169-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI