000			02738cam a2200445Ii 4500
988			_aSpringer_Medicine_2017
999			_c95025 _d95025 _x1
001			95025
003			ES-MaUEC
005			20230102112643.0
006			m o d
007			cr cnu---unuuu
008			161214s2017 sz ob 000 0 eng d
020			_a3319453955
020			_a3319453971 _q(electronic bk.)
020			_a9783319453958
020			_a9783319453972 _q(electronic bk.)
020			_z9783319453958
035			_a(OCoLC)965903422 _z(OCoLC)974651192 _z(OCoLC)981051277 _z(OCoLC)1005756832 _z(OCoLC)1011954023
040			_aN$T _cN$T _dN$T _dIDEBK _dGW5XE _dYDX _dAZU _dUAB _dCOO _dUPM _dOCLCF _dIOG _dVT2 _dESU _dJBG _dIAD _dICW _dICN _dOHI _dOTZ _dMERER _dOCLCQ _dU3W _dES-MaUEC _bspa
050		4	_aRC268.4 _b2017 EB
245	0	0	_aEx vivo engineering of the tumor microenvironment _cAmir R. Aref, David Barbie, editors
264		1	_aCham _bHumana Press _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	0		_aCancer drug discovery and development
500			_aSpringerLink
504			_aIncluye referencias bibliográficas
505	0		_a1. Introduction to Ex Vivo Cancer Models -- 2. Patient-derived Xenografts in Oncology -- 3.Organoid Culture: Applications in Development and Cancer -- 4. Microfluidics and future of cancer diagnostics -- 5. Advancing techniques and insights in circulating tumor cell (CTC) research -- 6. The Cancer Secretome -- 7. An overview of the tumor microenvironments and future of cancer therapy.
520	3		_aThis volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.
588	0		_aOnline resource; title from PDF title page (EBSCO, viewed December 20, 2016).
650		7	_9273952 _aCáncer _2embne _xAspectos genéticos
700	1		_aAref, Amir R., _eeditor literario
700	1		_aBarbie, David, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-45397-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI