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020 _a3319431390
_q(electronic bk.)
020 _a9783319431390
_q(electronic bk.)
020 _z3319431374
_q(hardcover ;
_qalk. paper)
020 _z9783319431376
_q(hardcover ;
_qalk. paper)
035 _a(OCoLC)965196118
_z(OCoLC)965710766
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050 4 _aRC280.U8
_bM654 2017 EB
245 0 0 _aMolecular genetics of endometrial carcinoma
_cLora Hedrick Ellenson, editor.
264 1 _aCham, Switzerland
_bSpringer
_c[2017]
264 4 _c2017
300 _a1 recurso en línea (xi, 281 páginas)
_bilustraciones (algunas a color)
336 _astill image
_bsti
_2rdacontent
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
490 0 _aAdvances in experimental medicine and biology
_x2214-8019
_vvolume 943
500 _aSpringerLink
504 _aIncluye referencias bibliográficas e índice
505 0 _aIntroduction. Epidemiology of endometrial carcinoma: etiologic importance of hormonal and metabolic influences / Ashley S. Felix, Hannah P. Yang, Daphne W. Bell [and others] -- Clinical behavior and treatment of endometrial cancer / Divya Gupta -- Pathology of endometrial carcinoma / Sigurd F. Lax -- Molecular profiling. Traditional approaches to molecular genetic analysis / Christopher J. Walker, Paul J. Goodfellow -- Next-generation sequencing / Matthieu Le Gallo, Fred Lozy, Daphne W. Bell -- Endometrial carcinoma: specific targeted pathways / Nuria Eritja, Andree Yeramian, Bo-Juen Chen, David Llobet-Navas [and others] -- Mouse models. LKB1 as a tumor suppressor in uterine cancer: mouse models and translational studies / Christopher G. Peña, Diego H. Castrillón -- Mig-6 mouse model of endometrial cancer / Tae Hoon Kim, Jung-Yoon Yoo, Jae-Wook Jeong -- PI3K/PTEN/AKT genetic mouse models of endometrial carcinoma / Ayesha Joshi, Lora Hedrick Ellenson.
520 3 _a"This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma"--Publisher's description.
588 0 _aOnline resource; title from pdf title page (SpringerLink, viewed December 6, 2016).
988 _aEBOOK, EBSPRINGER_2017B
650 7 _2embne
_9182312
_aÚtero
_xCáncer
700 1 _aEllenson, Lora Hedrick,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-43139-0
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b02/2018
_dz
_e-
_zSI