000			04546cam a2200397M 4500
001			94990
003			OCoLC
005			20230102112641.0
006			m o d
007			cr |n|||||||||
008			161202s2016 si o 000 0 eng d
020			_a9789811017506 _q(electronic bk.)
020			_a9811017506 _q(electronic bk.)
020			_z9789811017490
020			_z9811017492
035			_a(OCoLC)965146324 _z(OCoLC)964698614 _z(OCoLC)970610641
040			_aYDX _beng _cYDX _dOCLCQ _dN$T _dIDEBK _dEBLCP _dGW5XE _dOCLCF _dN$T _dUAB _dIOG _dESU _dJBG _dIAD _dICW _dICN _dOTZ _dOCLCQ _dU3W _dES-MaUEC _bspa
050		4	_aRJ482.R48 _b2017 EB
245	0	0	_aPediatric rheumatology : _ba clinical viewpoint / _cSujata Sawhney, Amita Aggarwal, editors.
264		1	_aSingapore _bSpringer International Publishing _c2016
300			_a1 recurso en línea
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aForeword; About the Editors; Preface; Contents; Contributors; Part I: Introduction to Pediatric Rheumatology; 1: History of Pediatric Rheumatology; References; Further Reading; 2: Basic Immunology for the Pediatrician; Introduction; Innate Immune Response; Effector Cells and Molecules; Adaptive Immune Response; Intracellular Signaling in Immune Cells; Drugs Acting on the Immune System/Mechanisms; Biological Agents [11]; Newer Synthetic Small Molecule Drugs; References; 3: Genetics of Pediatric Rheumatic Diseases; Monogenic or Mendelian Disorders and Complex Traits
505	8		_a4: Human Joint Anatomy and Physiology Anatomy and Physiology of Joints; Basic Concepts of Joints; Classification of Joints; Structural Components of Synovial Joint (Fig. 4.2); Nerve Supply to Joints; Other Structures Related to Joints; Concept of Synovio-entheseal Complexes; Changes in Joints with Aging; References; 5: Epidemiology of Pediatric Rheumatic Diseases; Introduction; Juvenile Idiopathic Arthritis; Dilemmas with Epidemiological Studies of JIA; Diagnostic Difficulties with JIA; Differences in Case Ascertainment for JIA; Factors Emerging with Passage of Time Regarding JIA
505	8		_aEstablishing the Genetic Basis of Rheumatic Diseases: Twin/Sibling Studies Dissecting the Genetic Basis of Complex Traits: Association and Linkage Studies; Candidate Gene Studies and Genome-Wide Studies; Statistical Considerations of Genomic Studies; Examples of Candidate Gene Studies in Pediatric Rheumatology; Associations with Rheumatic Diseases and Non-HLA Variants; Genome-Wide Studies in Pediatric Rheumatology; Genome-Wide Association Studies in Rheumatology; Immunochip; The Shared Genetics of Autoimmunity; Role of Whole-Exome Sequencing Studies; References
505	8		_aRacial Differences The Need for Improvement of the Classification System for JIA; Systemic Lupus Erythematosus; Epidemiology of Other Pediatric Rheumatological Disorders; References; 6: Trial Design and Collaborative Work in Pediatric Rheumatology; Introduction; The Challenges Associated with Clinical Trials in Pediatric Rheumatology; Networking and Pediatric Legislation; Trial Design; The Parallel Randomized Controlled Trial (RCT) with Placebo; The Parallel Randomized Controlled Trial (RCT) with Active Comparator Design; The Double-Blind, Controlled, Randomized Withdrawal Design
505	8		_aResponse to Treatment in Clinical Trials The Feasibility of JIA Clinical Trials; References; 7: Nonbiologic Drugs in Pediatric Rheumatology; Introduction; Basic Pharmacological Concepts; NSAIDs; Mechanism of Action; Pharmacology; General Principles of NSAID Therapy; Toxicity; Glucocorticoids; Physiological and Pharmacological Effects [1, 2]; Indications for Systemic Glucocorticoid Therapy; Adverse Effects; High-Dose Intravenous Glucocorticoid Therapy; Intra-articular Steroids; Disease-Modifying Antirheumatic Drugs (DMARDs); Methotrexate (MTX); Mechanism of Action [28, 29]
650		7	_aReumatología pediátrica _9164228
700	1		_aAggarwal, Amita, _eeditor literario _0http://id.loc.gov/authorities/names/nb2006027267 _1http://viaf.org/viaf/119459090
700	1		_aSawhney, Sujata, _eeditor literario _0http://id.loc.gov/authorities/names/nb2014013834 _1http://viaf.org/viaf/309833530
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-1750-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _ef _zSI
999			_c94990 _d94990 _x1