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007			cr |n|||||||||
008			161111s2017 sz o 000 0 eng d
020			_a3319435043 _q(electronic bk.)
020			_a9783319435046 _q(electronic bk.)
020			_z3319435027
020			_z9783319435022
035			_a(OCoLC)962412711 _z(OCoLC)962324847 _z(OCoLC)962852464 _z(OCoLC)965127211 _z(OCoLC)974650952 _z(OCoLC)1005804448
040			_aIDEBK _cIDEBK _dYDX _dEBLCP _dGW5XE _dOCLCQ _dOCLCF _dIDEBK _dUAB _dOH1 _dAZU _dCOO _dUPM _dOCLCO _dIOG _dOCLCO _dMERER _dOCLCO _dESU _dZ5A _dOCLCO _dJBG _dIAD _dOCLCO _dICW _dOCLCO _dICN _dOCLCO _dOCLCQ _dVT2 _dOCLCQ _dOCLCO _dN$T _dOCLCA _dU3W _dOCLCO _dES-MaUEC _bspa
050		4	_aR1 _b2017 EB
245	0	0	_aImaging biomarkers : _bdevelopment and clinical integration _cLuis Martí-Bonmatí, Angel Alberich-Bayarri, editors.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aThe shift in paradigm to precision medicine in imaging -- International initiatives for the promotion of imaging biomarkers -- Introduction to the stepwise development of imaging biomarkers -- Defining the biological basis and clinical question: proof of concept -- Looking for the inter-relationship: proof of mechanism -- Images acquisition: modality and protocol definition -- Images preparation -- Imaging biomarkers analysis -- Imaging biomarkers measurements -- Detecting measurement biases: the proof of principle -- Validating the imaging biomarker: the proof of efficacy and effectiveness -- The final step: Reporting imaging biomarkers results -- Sources of uncertainty: accuracy and precision of the measurements -- Pearls and pitfalls in Gold standards and biological correlation -- Imaging biobanks, big data and population-based imaging biomarkers -- A proposed Imaging Biomarkers analysis platform architecture for integration in clinics -- Use case I: Imaging biomarkers in neurodegenerative disease -- Use case II: Imaging biomarkers in tumors -- Use case III: Imaging biomarkers in thorax and heart -- Use case IV: Imaging biomarkers in musculoskeletal disorders -- Use case V: Imaging biomarkers in diffuse liver disease.
520	3		_aThis is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.
650		7	_aMarcadores biológicos _2embne _0(OCoLC)fst00831950 _0 _9162047
700	1		_aAlberich-Bayarri, Angel, _eeditor literario
700	1		_aMarti-Bonmati, L. _q(Louis), _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-43504-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _e- _zSI
999			_c94844 _d94844 _x1