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008			161105t20162017si o 000 0 eng d
020			_a9789811008399 _q(electronic bk.)
020			_a9811008396 _q(electronic bk.)
020			_z9789811008382
020			_z9811008388
035			_a(OCoLC)962154564 _z(OCoLC)961910167 _z(OCoLC)962017240
040			_aEBLCP _cEBLCP _dN$T _dYDX _dGW5XE _dN$T _dOCLCQ _dIDEBK _dOCLCF _dUAB _dIOG _dESU _dJBG _dIAD _dICW _dICN _dOTZ _dOCLCQ _dU3W _dES-MaUEC _bspa
050		4	_aRC776.O3 _b2017 EB
245	0	0	_aChronic obstructive pulmonary disease : _ba systemic inflammatory disease _cHiroyuki Nakamura, Kazutetsu Aoshiba, editors.
264		1	_aSingapore _bSpringer International Publishing
300			_a1 recurso en línea (351 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aRespiratory Disease Series: Diagnostic Tools and Disease Managements
505	0		_aPreface; References; Contents; Part I: Definition and Epidemiology; Chapter 1: Definition of Chronic Obstructive Pulmonary Disease (COPD): Is the Latest GOLD Classification of Severity Still Val ... ; 1.1 Introduction; 1.2 Historical Transition of the Concept of COPD; 1.3 Difference Between COPD and Bronchial Asthma; 1.4 Chronic Bronchitis and Pulmonary Emphysema; 1.5 Global Initiative for Chronic Obstructive Lung Disease (GOLD); 1.6 Combined COPD Assessment; 1.7 Conclusion; References; Chapter 2: Epidemiology of COPD: Why Is the Disease So Poorly Recognized?; 2.1 Introduction.
505	8		_a2.2 Risk Factors of COPD2.2.1 Cigarette Smoking; 2.2.2 Other Risk Factors; 2.2.2.1 Genetic Factors; 2.2.2.2 Environmental Factors; Occupational Airborne Particles; Air Pollution; Indoor Air Pollutants; Outdoor Air Pollution; 2.2.2.3 Low Socioeconomic Status; 2.3 Decline in FEV1 in Patients with COPD; 2.4 Incidence of COPD; 2.5 Prevalence of COPD; 2.6 Undiagnosed COPD; 2.7 Impact of COPD on Health Status in the General Population; 2.8 Conclusions; References; Part II: Genetic Predisposition and Pathogenic Mechanisms.
505	8		_a3.6 Recent Progress of Studies of COPD Genetics in GWAS Era (III): Novel Strategy for Research on COPD Genetics with Multi-omi ... 3.7 Recent Progress of Studies of COPD Genetics in GWAS Era (IV): Next-Generation Sequencing and Arrays; 3.8 Recent Progress of Studies of COPD Genetics in GWAS Era (V): Pharmacogenetics and Pharmacogenomics in COPD; 3.9 Conclusions; References; Chapter 4: Pathogenesis of COPD (Persistence of Airway Inflammation): Why Does Airway Inflammation Persist After Cessation of ... ; 4.1 Introduction; 4.2 Airway Inflammation and Changes in COPD.
505	8		_a4.2.1 Airway Structure and Mucus Production in Patients with COPD4.2.2 Lung Destruction in COPD; 4.2.3 Inflammatory Cells and Cytokines in the Airway in COPD; 4.3 Airway Inflammation After Smoking Cessation; 4.3.1 Innate Immune System; 4.3.1.1 The Role of TLRs; 4.3.1.2 The Role of NLRs; 4.3.1.3 The Role of RLRs; 4.3.1.4 The Role of RAGE; 4.3.2 Adaptive Immune System; 4.3.2.1 The Role of B Cells; 4.3.2.2 The Role of T Cells; 4.3.3 COPD Deterioration After Smoking Cessation; 4.3.3.1 COPD Deterioration by COPD Itself; 4.3.3.2 COPD Deterioration by Latent Respiratory Infection.
505	8		_aChapter 3: Genetic Predisposition to COPD: Are There Any Relevant Genes Determining the Susceptibility to Smoking?3.1 Introduction; 3.2 Investigation of the Genes Related to COPD Pathogenesis: The Era Before GWAS; 3.3 Genome-Wide Association Studies (GWASs) for Susceptibility Genes of COPD; 3.4 Recent Progress of Studies of COPD Genetics in GWAS Era (I): Relevant Genes Determining the Susceptibility to Smoking; 3.5 Recent Progress of Studies of COPD Genetics in GWAS Era (II): Gene Related to Critical Subtypes or Phenotypes of COPD.
650		7	_aEnfermedad pulmonar obstructiva crónica _2embne _0(OCoLC)fst01003801 _0 _9155837
700	1		_aAoshiba, Kazutetsu. _9100389
700	1		_aNakamura, Hiroyuki. _9100388
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-0839-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _e- _zSI
999			_c94827 _d94827 _x1