000			03569nam a22003735i 4500
001			88413
003			ES-MaUEC
005			20230207040632.0
007			cr nn 008mamaa
008			161118s2016 gw | s |||| 0|eng d
020			_a9783319319643
024	7		_a10.1007/978-3-319-31964-3 _2doi
040			_aES-MaUEC
050		4	_aRC514 _b.B853 2016 EB
100	1		_aBulayeva, Kazima _9102067 _0Local
245	1	0	_aGenomic Architecture of Schizophrenia Across Diverse Genetic Isolates : _bA Study of Dagestan Populations _cby Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
260			_aCham, Switzerland _bSpringer _c2016
300			_a1 recurso en línea (XXVIII, 142 p.) _b50 ilustraciones, 35 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1 Current Problems of Complex Disease Genes Mapping -- 2 Descriptions and Methods of Study in Selected Genetic Isolates of Dagestan -- 3 Selection of Populations for Mapping Genes of Complex Diseases -- 4 Mapping Genes of Schizophrenia in Selected Dagestan Isolates -- 5 Common Structural Genomic Variants in Linked with SCZ Regions.
520			_aThis book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aEsquizofrenia _9140524 _0comprobar BNE19900986340 _2embne
700	1		_aBulayev, Oleg _9102068 _0Local
700	1		_aGlatt, Stephen _9102069 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-31964-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319319643
907			_a.b12984206 _b10-10-17 _c22-03-17
998			_am _a_alco _a_vill _b21-03-17 _cm _dz _ea _feng _ggw _h0
945			_aRC514 .B853 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11605248 _z06-04-17
999			_c88413 _d88413 _x1