000			03492nam a22003615i 4500
001			88406
003			ES-MaUEC
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007			cr nn 008mamaa
008			161123s2016 xxu| s |||| 0|eng d
020			_a9781493964604
024	7		_a10.1007/978-1-4939-6460-4 _2doi
040			_aES-MaUEC
050		4	_aRC267 _b.F766 2016 EB
245	1	0	_aFrontiers in Cancer Research : _bEvolutionary Foundations, Revolutionary Directions _cedited by Carlo C. Maley, Mel Greaves
260			_aNew York _bSpringer _c2016
300			_a1 recurso en línea (XIV, 258 p.) _b28 ilustraciones, 17 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1. The Evolutionary Foundations of Cancer Research -- 2. The Role of Theory in Cancer Research -- 3. Population Genetics of Neoplasms -- 4. Diversity in Neoplasms -- 5. How do Mutant Clones Expand in Normal Tissue? -- 6. Cancer Stem Cells in Tumor Evolution -- 7. Measuring Rather than Imagining Somatic Cell Selection and Clonal Evolution -- 8. The Darwinian Dynamics of Motility and Metastasis -- 9. Applying Evolutionary Principles to Cancer Therapy -- 10. Mismatches with Our Ancestral Environments and Cancer Risk -- 11. The Evolution of Cancer Suppression Mechanisms -- 12. Epilogue: How can we Thwart the Evolutionary Resilience of Cancer?.
520			_aThis is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aCáncer _xInvestigación _0comprobar BNE19901364217 _2embne _9182523
700	1		_aMaley, Carlo C. _eeditor literario _9102054 _0Local
700	1		_aGreaves, Mel. _eeditor literario _934148 _0comprobar BNE20021535206
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-6460-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781493964604
907			_a.b12984139 _b10-10-17 _c22-03-17
998			_am _a_alco _a_vill _b21-03-17 _cm _dz _ea _feng _gxxu _h0
945			_aRC267 .F766 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11605170 _z06-04-17
999			_c88406 _d88406 _x1