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001			88404
003			ES-MaUEC
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007			cr nn 008mamaa
008			161112s2016 xxu| s |||| 0|eng d
020			_a9781493937370
024	7		_a10.1007/978-1-4939-3737-0 _2doi
040			_aES-MaUEC
050		4	_aQP572.T5 _bT497 2016 EB
245	0	0	_aThyroid Hormone Disruption and Neurodevelopment _cedited by Noriyuki Koibuchi, Paul M. Yen
260			_aNew York _bSpringer _c2016
300			_a1 recurso en línea (VIII, 209 p.) _b22 ilustraciones, 16 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aContemporary Clinical Neuroscience
505	0		_aSection 1: Disruption of thyroid hormone action at molecular level -- 1 Molecular mechanisms of thyroid hormone action in brain: a general overview -- 2 Deoidinases and brain development -- 3 Disruption of thyroid hormone receptor-mediated action in brain by endocrine disrupting chemicals -- 4 Chemical disruption of deiodinase activities during pregnancy and fetal neurotoxicity -- 5 Effect of maternal/neonatal infection on thyroid hormone-mediated neurodevelopment -- 6 Disruption of feedback regulation of thyroid hormone synthesis/secretion and brain development -- Section 2: Animal models to study thyroid hormone disruption on neurodevelopment -- 7 Animal models to study thyroid hormone action in neurodevelopment -- 8 Thyroid hormone receptor mutation and neurodevelopment -- 9 Pax6 knockout and cerebellar development -- 10 Disruption of auditory function by thyroid hormone receptor mutation -- Section 3 Thyroid hormone disruption and neurodevelopment: human studies -- 11 Maternal hypothyroidism and brain development of newborns -- 12 Congenital hypothyroidism and neurodevelopment -- 13 Iodine deficiency and brain development -- 14 Deficit in thyroid hormone transporters and brain development -- 15 Syndrome of resistance to thyroid hormone and brain development.
520			_aThyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a zrepressory of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. .
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aHormonas tiroideas _9144300 _0comprobar BNE19912516767 _2embne
650		7	_aEndocrinología _0comprobar BNE19900971669 _2embne _9139372
700	1		_aKoibuchi, Noriyuki _eeditor literario _0Local _986020
700	1		_aYen, Paul M. _eeditor literario _9102051 _0Local
830		0	_aContemporary Clinical Neuroscience _0http://id.loc.gov/authorities/names/n00120987 _9133160
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-3737-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781493937370
907			_a.b12984115 _b10-10-17 _c22-03-17
998			_am _a_alco _a_vill _b21-03-17 _cm _dz _ea _feng _gxxu _h0
945			_aQP572.T5 T497 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11605157 _z06-04-17
999			_c88404 _d88404 _x1