000			03401nam a22003855i 4500
999			_c88299 _d88299 _x1
001			88299
003			ES-MaUEC
005			20230207040631.0
006			a||||fo|||| 00| 0
007			cr nn 008mamaa
008			161221s2016 si | s |||| 0|eng d
020			_a9789811021138
024	7		_a10.1007/978-981-10-2113-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRM411 _b2016 EB
245	0	0	_aPharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs _cedited by Tony K. L. Kiang, Kyle John Wilby, Mary H. H. Ensom
264		1	_aSingapore _bSpringer _c2016
300			_a1 recurso en línea (VII, 135 páginas) _b40 ilustraciones, 25 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1. Introduction -- 2. HIV-Associated Comorbidities -- 3. Pharmacology and Pharmacokinetic Properties of Available Antiretrovirals -- 4. In Vitro Reaction Phenotyping and Drug Interaction Data -- 5. Clinical Drug-Drug Interaction Data: Effects of Co-administered Drugs on Pharmacokinetics of Antiretroviral Agents -- 6. Clinical Drug-Drug Interaction Data: Effects of Antiretroviral Agents on Co-administered Drugs -- 7. Pharmacodynamic Interactions Between Antiretrovirals and Other Agents -- 8. Conclusion and Clinical Decision Algorithm.
520			_aClinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today.
988			_aEBOOK, EBSPRINGER
650	0	7	_aAntirretrovirales _9161207 _2embne
650	0	7	_aFarmacología _2embne _9137893
700	1		_aKiang, Tony K. L. _eeditor literario _0Local _994973
700	1		_aWilby, Kyle John _eeditor literario _0Local _994974
700	1		_aEnsom, Mary H. H. _eeditor literario _0Local _994975
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-981-10-2113-8zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12983032 _b10-10-17 _c08-03-17
942			_2lcc _cLE
945			_g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11604876 _z06-04-17
998			_b06/2020 _dz _eu _feng _gsi _h0