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008			161117s2016 ne | s |||| 0|eng d
020			_a9789402409628
024	7		_a10.1007/978-94-024-0962-8 _2doi
040			_aES-MaUEC
050		4	_aQP551 _b.S57 2016 EB
245	0	0	_aSirtuins _cedited by Riekelt H. Houtkooper
260			_aDordrecht _bSpringer _c2016
300			_a1 recurso en línea (VIII, 288 p.) _b30 ilustraciones, 24 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aProteins and Cell Regulation _v10
505	0		_aGeneral introduction, Riekelt H. Houtkooper -- Biochemistry and Enzymology of Sirtuins, Yue Yang and Anthony A. Sauve -- NAD+ as a pharmacological tool to boost sirtuin activity, Riekelt H. Houtkooper -- Protein lysine acylation: abundance, dynamics and function, Olga Pougovkina and Vincent C. J. de Boer -- SIRT1 in metabolic health and disease, Marie Boutant and Carles Cantó -- Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function, Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey -- SIRT5 reveals novel enzymatic activities of sirtuins, Bin He and Hening Lin -- Diverse roles for SIRT6 in mammalian healthspan and longevity, Bernadette M. M. Zwaans, William Giblin and David B. Lombard -- Sirtuins in cancer \2013 emerging role as modulators of metabolic reprogramming, Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis -- Sirtuins as metabolic modulators of muscle plasticity, Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx -- Sirtuins and aging, Carles Cantó and Riekelt Houtkooper -- Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk, Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi -- Sirtuin activation by small molecules, Hassina Massudi, Lindsay E. Wu, and David A. Sinclair -- Future perspective, Brian Kennedy -- Index
520			_aThe sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aProteínas _0comprobar BNE19900977845 _2embne _9139861
650	0	4	_9668476 _aQuímica bioorgánica _0LocalZ
650		7	_aMetabolismo _xTrastornos _0comprobar BNE19901051669 _2embne _9168790
700	1		_aHoutkooper, Riekelt H. _eeditor literario _9101940 _0Local
830		0	_aProteins and Cell Regulation _v10 _9133399
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-024-0962-8zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9789402409628
907			_a.b12982945 _b10-10-17 _c08-03-17
998			_am _a_alco _a_vill _b19-06-17 _cm _dz _eb _feng _gne _h0
945			_aQP551 .S57 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11604785 _z06-04-17
999			_c88290 _d88290 _x1