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008			161222s2016 gw | s |||| 0|eng d
020			_a9783319492841
024	7		_a10.1007/978-3-319-49284-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQR46 _b2016 ES
245	0	0	_aHow to Overcome the Antibiotic Crisis : _bFacts, Challenges, Technologies and Future Perspectives _cedited by Marc Stadler, Petra Dersch
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XII, 496 páginas)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v398
505	0		_aTackling threats and future problems of multidrug-resistant bacteria.-Emergence and spread of antimicrobial resistance: recent insights from bacterial population genomics -- Epidemiology of Staphylococcus aureus nasal carriage patterns in the community -- Diagnostics and resistance profiling of bacterial pathogens -- Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus suis.-Antibiotics and the intestinal microbiome: individual responses, resilience of the ecosystem and the susceptibility to infections -- Anti-virulence strategies to target bacterial infections -- Strategies to block bacterial pathogenesis by interference with motility and chemotaxis -- New horizons in the development of novel needle-free immunization strategies to increase vaccination efficacy -- History of antibiotics research -- Actinobacteria and Myxobacteria Two of the most important bacterial resources for novel antibiotics -- Exploitation of fungal biodiversity for discovery of novel antibiotics -- Strategies for the discovery and development of new antibiotics from natural products: Three Case Studies -- New structural templates for clinically validated and novel targets in antimicrobial drug research and development -- Synthesis of antibiotics -- Antibiotics clinical development and pipeline -- Anti-infectives in drug delivery overcoming the Gram-negative bacterial cell envelope.
520			_aThis volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the zbad bugsy are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.
988			_aEBOOK, EBSPRINGER
650	0	4	_9405049 _aMicrobiología médica _2embne
650	0	7	_aFarmacología _2embne _9137893
700	1		_aStadler, Marc. _eeditor literario _9101837 _0Local
700	1		_aDersch, Petra _eeditor literario _0Local _9101838
830		0	_aCurrent Topics in Microbiology and Immunology _x0070-217X _v398 _0http://id.loc.gov/authorities/names/n42036058 _9133248
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-49284-1zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319492841
907			_a.b12982520 _b10-10-17 _c08-03-17
942			_2lcc _cLE
945			_aQR46 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11604360 _z06-04-17
998			_b06/2020 _dz _eu _feng _ggw _h0