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008			161124s2016 gw | s |||| 0|eng d
020			_a9783319480787
024	7		_a10.1007/978-3-319-48078-7 _2doi
040			_aES-MaUEC
050		4	_aQH450 _b.W355 2016 EB
100	1		_aWallace, Rodrick _0http://id.loc.gov/authorities/names/n78004714 _0Local _999775
245	1	0	_aGene Expression and Its Discontents : _bThe Social Production of Chronic Disease _cby Rodrick Wallace, Deborah Wallace.
250			_a2nd ed. 2017.
260			_aCham, Switzerland _bSpringer _c2016
300			_a1 recurso en línea (XIII, 344 p.) _b52 ilustraciones
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction -- 1. Toward new tools -- 2. Models of development -- 3. Groupoid symmetries -- 4. Epigenetic catalysis -- 5. Developmental disorders -- 6. An interim perspective -- 7. The obesity pandemic in the US -- 8. Coronary heart disease in the US. - 9. Cancer: a developmental perspective -- 10. Autoimmune disorders -- 11. Demoralization and obesity in Upper Manhattan -- 12. Death at an early age: AIDS and related mortality in New York City -- 13. Mental Disorders I: Western atomism and its culture-bound syndromes -- 14. Mental Disorders II: Psychopathology and sleep -- 15. Diabetes and Thyroid Cancer in Manhattan's Chinatown -- 16. Right-To-Work Laws and Alzheimer's Disease -- 17. Stress as an Environmental Exposure -- 18. Final Thoughts -- 19. Mathematical Appendix.
520			_aThis book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer�s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.
650	0	7	_9162770 _aExpresión génica _2embne
650	0	7	_aEnfermedades crónicas _2embne _9151368
700	1		_aWallace, Deborah _0Local _9101811
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-48078-7zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319480787
907			_a.b12982404 _b10-10-17 _c08-03-17
942			_2lcc _cLE
945			_aQH450 .W355 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11604244 _z06-04-17
988			_aEBOOK, EBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0