000			03385nam a22004575i 4500
999			_c88221 _d88221 _x1
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008			170124s2016 gw | s |||| 0|eng d
020			_a9783319473888
024	7		_a10.1007/978-3-319-47388-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH324.2 _b2016 EB
100	1		_aKoča, Jaroslav _9101774 _0Local
245	1	0	_aStructural Bioinformatics Tools for Drug Design : _bExtraction of Biologically Relevant Information from Structural Databases _cby Jaroslav Koca, Radka Svobodová Vareková, Luká Pravda, Karel Berka, Stanislav Geidl, David Sehnal, Michal Otyepka
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XIII, 144 páginas) _b62 ilustraciones
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringerBriefs in Biochemistry and Molecular Biology _x2211-9353
505	0		_a1. Introduction -- 2. Biomacromolecular fragments -- 3. Databases -- 4. Detection & Extraction -- a. Biomacromolecular fragments and structural patterns -- b. channels and pores -- 5. Validation -- 6. Characterization -- a. Partial atomic charges -- b. Channel characteristics -- 7. Selected Examples.
520			_aA large amount of structural data on biomacromolecules is available and the number of resolved structures is growing rapidly. This implies that we have an increasing opportunity to perform so far unprecedented analyses to obtain crucial biological insight. Biomacromolecular structural fragments such as binding sites or active sites, ligands, channels, pores, secondary structure motifs, etc., become very promising objects for these analyses because such fragments often serve as drug targets or drug templates, or substrate-specific pathways. However, such analyses are very challenging due to their complexity and, consequently, also because they require application of a combination of different software tools. In this book, we describe individual steps necessary for analysis of biomacromolecular fragments and provide a lsit of software tools required to perform such steps. For each step, we also show corresponding web-based tools in detail and provide a few practical examples of their usage.
988			_aEBOOK, EBSPRINGER
650		7	_aBioinformática _2embne _9160489
650		7	_aDrogas de diseño _2embne _9157991
700	1		_aSvobodová Vareková, Radka. _9101775 _0Local
700			_aPravda, Luká _9101776 _0Local
700	1		_aBerka, Karel _0Local _9101777
700	1		_aGeidl, Stanislav _0Local _9101778
700	1		_aSehnal, David. _9101779 _0Local
700	1		_aOtyepka, Michal. _9101780 _0Local
830		0	_aSpringerBriefs in Biochemistry and Molecular Biology _x2211-9353 _0http://id.loc.gov/authorities/names/no2012070367 _9133204
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-47388-8zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12982258 _b10-10-17 _c08-03-17
942			_2lcc _cLE
945			_g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11604098 _z06-04-17
998			_b06/2020 _dz _eu _feng _ggw _h0