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020 _a9783319462400
024 7 _a10.1007/978-3-319-46240-0
_2doi
040 _aES-MaUEC
050 4 _aQP519.9.M3
_bC375 2016 EB
245 0 0 _aCapillary Electrophoresis-Mass Spectrometry :
_bTherapeutic Protein Characterization
_cedited by James Q. Xia, Lichao Zhang
260 _aCham
_bSpringer International Publishing
_c2016
300 _a1 recurso en línea (IX, 74 p.)
_b28 ilustraciones, 21 ilustraciones en color
336 _aTexto (visual)
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
505 0 _aIntroduction to Capillary Electrophoresis{u2014}Mass Spectrometry -- Coated Capillaries for CE-MS of Therapeutic Protein -- Intact Mass Analysis of Monoclonal Antibodies by Capillary Electrophoresis-Mass Spectrometry -- Separation and Characterization of Proteins and Peptides in Biological Fluids using CE-MS -- Host Cell Protein Analysis using CE-MS -- Antibody PTM Analysis using CE-MS -- Characterization of Intact Therapeutic Proteins and Protein Subunits using CE-MS Platform
520 _aThis book covers the latest developments in capillary electrophoresis-mass spectrometry for the analysis of therapeutic proteins. The application of capillary electrophoresis-mass spectrometry (CE-MS) coupling technology in the analysis of recombinant therapeutic proteins is detailed thoroughly. Specific topics include recent developments in coupling capillary electrophoresis with mass spectrometry for the quality control of monoclonal antibody therapeutics, top-down analysis of monoclonal antibody using the CE-MS platform, and detection of host cell protein impurities. Comprehensive characterization of antibody-drug conjugates (ADCs) by coupling capillary electrophoresis with mass spectrometry is also covered. This is an ideal book for scientists in the life science and biopharmaceutical industry who are working on characterizing the PTMs of monoclonal antibodies, as well as graduate students and researchers in the separation science and biological mass spectrometry fields
942 _2lcc
_cLE
988 _aEBOOK, EBSPRINGER
650 7 _aEspectrometría de masas
_0comprobar BNE19900999041
_2embne
_9141447
650 7 _aProteínas
_0comprobar BNE19900977845
_2embne
_9139861
650 7 _aMicroscopia
_9138719
_0comprobar BNE19900963390
_2embne
700 1 _aXia, James Q.
_eeditor literario
_9101708
_0Local
700 1 _aZhang, Lichao
_eeditor literario
_9101709
_0Local
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-46240-0zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901 _ai9783319462400
907 _a.b12981916
_b27-10-17
_c08-03-17
998 _am
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_a_vill
_b27-10-17
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_dz
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