000			03707nam a22003855i 4500
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001			88183
003			ES-MaUEC
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007			cr nn 008mamaa
008			161219s2016 gw | s |||| 0|eng d
020			_a9783319460444
024	7		_a10.1007/978-3-319-46044-4 _2doi
040			_aES-MaUEC
050		4	_aRC321-580 EB
245	1	0	_aGABAB Receptor _cedited by Giancarlo Colombo.
260			_aCham _bSpringer International Publishing _bImprint: Humana Press _c2016.
300			_a1 recurso en línea (XX, 385 p.) _b64 ilustraciones, 19 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aThe Receptors _v29
505	0		_a1. Historical Perspectives on the GABAB Receptor -- Section 1. Chemistry -- 2. Chemistry of GABAB Receptor Ligands: Focus on Agonists and Antagonists -- 3. Chemistry of GABAB Receptor Ligands: Focus on Positive Allosteric Modulators -- Section 2. Molecular Biology, Biochemistry, & Physiology -- 4. Molecular Structure and Trafficking of the GABAB Receptor -- 5. Distribution and Localization of the GABAB Receptor -- 6. Activation Mechanism and Allosteric Properties of the GABAB Receptor -- 7. Modulation of Neurotransmission by the GABAB Receptor -- 8. GABAB Receptor Functions In The Mesolimbic Dopamine System -- Section 3. Pharmacology -- 9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABAB Receptor Ligands -- 10. Targeting the GABAB Receptor for the Treatment of Epilepsy -- 11. Targeting the GABAB Receptor for the Treatment of Pain -- 12. Targeting the GABAB Receptor for the Treatment of Psychiatric Disorders -- 13. Targeting the GABAB Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders -- 14. Targeting the GABAB Receptor for the Treatment of Substance Use Disorder -- 15. Targeting the GABAB Receptor for the Treatment of Alcohol Use Disorder -- 16. Targeting GABAB Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough -- 17. Baclofen: Therapeutic Use and Potential of the Prototypic GABAB Receptor Agonist -- 18. Allosteric Modulators: The New Generation of GABAB Receptor Ligands -- 19. GABAB Receptor Antagonists as Cognition Enhancers.
520			_aAn up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.
650		7	_aNeurociencias _2embne _9158907
650		7	_aNeurología _2embne _9139040
700	1		_aColombo, Giancarlo. _eeditor literario _99472 _0comprobar BNE19961808771
830		0	_aThe Receptors _v29 _9133208
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-46044-4zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319460444
907			_a.b12981874 _b10-10-17 _c08-03-17
942			_2lcc _cLE
945			_aRC321-580 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11603719 _z06-04-17
988			_aEBOOK, EBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0