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001			88171
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007			cr nn 008mamaa
008			161125s2016 gw s 000 0 eng d
020			_a9783319450964
024	7		_a10.1007/978-3-319-45096-4 _2doi
040			_aES-MaUEC
050		4	_aQP562.G5 _bG58 2016 EB
245	0	4	_aThe Glutamate/GABA-Glutamine Cycle : _bAmino Acid Neurotransmitter Homeostasis _cedited by Arne Schousboe, Ursula Sonnewald
260			_aCham, Switzerland _bSpringer _c2016
300			_a1 recurso en línea (X, 416 p.) _b55 ilustraciones, 42 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Neurobiology _x2190-5215 _v13
505	0		_aIntroduction to the Glutamate-Glutamine cycle -- Glucose, lactate, Ý-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine-glutamate/GABA cycle -- Anaplerosis for glutamate synthesis in the neonate and in adulthood -- Enzyme complexes important for the glutamate-glutamine cycle -- BCAA metabolism and NH3 homeostasis -- Glutaminases Vesicular Glutamate Uptake -- The glutamine transporters and their role in the Glutamate/GABA-Glutamine Cycle -- Glutamine Metabolism in Gliomas -- Oligodendrocytes: development, physiology and glucose metabolism -- Dysregulation of glutamate cycling mediates methylmercury-induced neurotoxicity -- Astroglia, glutamatergic transmission and psychiatric diseases -- Glutamine Synthetase: Role in Neurological Disorders -- The Glutamate ; Glutamine Cycle in Epilepsy -- Index
520	3		_aFundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term zThe Glutamate-Glutamine Cycle.y In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aÁcido glutámico _9155047 _0comprobar BNE19985024102 _2embne
650		7	_aNeurociencias _0comprobar BNE20012490612 _2embne _9158907
700	1		_aSchousboe, Arne _eeditor literario _985261 _0Local
700	1		_aSonnewald, Ursula _eeditor literario _9101676 _0Local
830		0	_aAdvances in Neurobiology _x2190-5215 _v13 _0http://id.loc.gov/authorities/names/no2011033665 _9133189
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-45096-4zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319450964
907			_a.b12981758 _b10-10-17 _c08-03-17
998			_am _a_alco _a_vill _b30-08-17 _cm _dz _eu _feng _ggw _h4
945			_aQP562 .G5 G58 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11603598 _z06-04-17
999			_c88171 _d88171 _x1