000			04105nam a22003975i 4500
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001			88156
003			ES-MaUEC
005			20230207040625.0
007			cr nn 008mamaa
008			161108s2016 gw s 000 0 eng d
020			_a9783319436241
024	7		_a10.1007/978-3-319-43624-1 _2doi
040			_aES-MaUEC
050		4	_aQP606.M48 _bD53 2016 EB
245	0	0	_aDNA Methyltransferases - Role and Function _cedited by Albert Jeltsch, Renata Z. Jurkowska
260			_aCham, Switzerland _bSpringer _c2016
300			_a1 recurso en línea (VIII, 535 p.) _b61 ilustraciones, 57 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v945
505	0		_aMechanisms and biological roles of DNA methylation and DNA methyltransferases from past achievements to future challenges -- DNA and RNA pyrimidine nucleobase alkylation at the carbon-5 position -- Bacterial DNA methylation and methylomes -- Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases -- Enzymology of mammalian DNA methyltransferases -- Genetic studies on mammalian DNA methyltransferases -- The role of DNA methylation in cancer -- Structure and mechanism of plant DNA methyltransferases -- DNA methylation and gene regulation in honey bees: from genome-wide analyses to obligatory epi-alleles -- N6-methyladenine: a conserved and dynamic DNA mark -- Pathways of DNA demethylation -- Structure and function of TET enzymes -- Proteins that read DNA methylation -- DNA base flipping a general mechanism for writing, reading, and erasing DNA modifications -- Current and emerging technologies for the analysis of the genome-wide and locus-specific DNA methylation patterns -- DNA methyltransferase inhibitors development and applications -- Rewriting DNA methylation signatures at will: the curable genome within reach? -- Engineering and directed evolution of DNA methyltransferases -- DNA labeling using DNA methyltransferases.
520	3		_aDNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics
650		7	_aEnzimas _0comprobar BNE19900962355 _2embne _9138640
650		7	_aADN _0comprobar BNE19900989837 _2embne _9140806
700	1		_aJeltsch, Albert _eeditor literario _9101629 _0Local
700	1		_aJurkowska, Renata Z. _eeditor literario _0Local _9101630
830		0	_aAdvances in Experimental Medicine and Biology _x0065-2598 _v945 _0http://id.loc.gov/authorities/names/n42001229 _9133153
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-43624-1zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319436241
907			_a.b12981606 _b10-10-17 _c08-03-17
942			_2lcc _cLE
945			_aQP606 .M48 D53 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11603446 _z06-04-17
988			_aEBOOK, EBSPRINGER
998			_am _a_alco _a_vill _b26-07-17 _cm _dz _eu _feng _ggw _h0