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008			161110s2016 gw | s |||| 0|eng d
020			_a9783319415239
024	7		_a10.1007/978-3-319-41523-9 _2doi
040			_aES-MaUEC
050		4	_aQP552.G16 _bA344 2016 EB
245	1	0	_aAdhesion G Protein-coupled Receptors : _bMolecular, Physiological and Pharmacological Principles in Health and Disease _cedited by Tobias Langenhan, Torsten Schöneberg
260			_aCham, Switzerland _bSpringer _c2016
300			_a1 recurso en línea (XIV, 403 p.) _b68 ilustraciones, 67 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aHandbook of Experimental Pharmacology _x0171-2004 _v234
505	0		_aPART I. Molecular and Pharmacological Properties of Adhesion GPCRs:-Classification, Nomenclature and Structural Aspects of Adhesion GPCRs -- 7TM Domain Structure of Adhesion GPCRs -- Understanding the Structural Basis of Adhesion GPCR Functions.-Control of Adhesion GPCR Function Through Proteolytic Processing.-Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs -- Versatile Signaling Activity of Adhesion GPCRs -- Adhesion GPCR-Related Protein Networks.-The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans -- PART II: Adhesion GPCRs as Pharmakotargets in Organ Function and Development -- Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors -- Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration -- Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.-Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs -- Adhesion GPCR Function in Pulmonary Development and Disease.-Adhesion GPCRs as Modulators of Immune Cell Function.-Heart Development, Angiogenesis, and Blood-Brain Barrier Function is Modulated by Adhesion GPCRs.-Adhesion GPCRs in Tumorigenesis.
520			_aLatest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
650		7	_aProteínas G _2embne _9147588
650		7	_aCitología _2embne _9139477
650		7	_aGenética humana _2embne _9140562
700	1		_aLangenhan, Tobias _eeditor literario _0Local _9101580
700	1		_aSchöneberg, Torsten. _eeditor literario _9101581 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-41523-9 _zSolo usuarios Universidad Europea
901			_ai9783319415239
907			_a.b12981291 _b10-10-17 _c08-03-17
942			_2lcc _cLE
945			_aQP552.G16 A344 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11603136 _z06-04-17
988			_aEBOOK, EBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0