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008			170107s2016 gw | s |||| 0|eng d
020			_a9783319414218
024	7		_a10.1007/978-3-319-41421-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aR857 .N34 _b2016 EB
245	0	0	_aPolymer Nanoparticles for Nanomedicines : _bA Guide for their Design, Preparation and Development _cedited by Christine Vauthier, Gilles Ponchel
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XXIX, 641 páginas) _b115 ilustraciones, 80 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface -- Introduction Part I: Polymer nanoparticles for in vivo applications: Progress on preparation methods and future challenges -- Nanoprecipitation process: From particlepreparation to in vivo applications -- Targeted Theragnostic Nanoparticles via Flash Nanoprecipitation: Principles of Materials Selection -- Preparation of polymer nanoparticles by the emulsification-solvent evaporation method: from Vanderhoffś pioneer approach to recent adaptations -- Methods for the preparation of nanoparticles by polymerization -- Shape-controlled nanoparticles for drug delivery and targeting applications -- Physicochemical characterization of polymer nanoparticles: Challenges and present limitations -- Imaging polymer nanoparticles by means of transmission and scanning electron microscopy techniques -- Evaluating the interactions between proteins and components of the immune system with polymer nanoparticles -- Investigating interactions between nanoparticles and cells: internalization and intracellular trafficking -- Characterization of mucoadhesive interactions between nanoparticles and epithelial membranes -- Designing polymer nanoparticle nanomedicines: potential applications and challenges -- Selecting and designing polymers suitable for nanoparticles manufacturing -- Associating Drugs with Polymer Nanoparticles: A Challenge -- Drug delivery by nanoparticles: The Challenge of Controlled Release and Evaluation -- Interaction between nanoparticles and plasma proteins: effects on nanoparticle biodistribution and toxicity -- Toxicological aspects of polymer nanoparticles -- Theranostics: In Vivo -- Nanomedicines A scientific toy or an emerging market? -- Regulatory perspective on the development of polymeric nanomaterials.
520			_aNanomedicines comprise a wide range of nanotechnologies including various types of nanoparticles developed as therapeutic, diagnostic and theranostic agents. The translation of nanoparticles in the clinical setting is rapidly progressing. It is now a quite well-established idea that the ultimate in vivo efficacy of nanoparticles is closely related to their characteristics. However, defining specification and designing nanoparticles based on scientifically sound justifications remains an obstacle. Another hurdle concerns the production of the nanoparticles in the requirements of clinical batch manufacturing and quality control. In these challenges, polymer nanoparticles are unique. Their characteristics can be finely tuned during synthesis and post-synthesis to cover the broad range of specificity that can be defined, with a high level of precision needed to make their in vivo application successful. Their methods of synthesis can be quite precise and most of them are scalable. The topic of the present book covers all steps of the development of polymer nanoparticles to be used as therapeutic or diagnostic nanomedicine. It is aimed to guide researchers, entrepreneurs, engineers, postdoctoral and Ph.D. students in their decisions for the design and development of nanomedicines occurring as polymer nanoparticles. The book is divided into four sections. The first and second parts describe experimental protocols as well as the methods of manufacturing and the methods of characterization that were specifically developed to be applied during the development of polymer-based nanomedicines. The third section includes a series of chapters that discusses the different topics that are accounted for while designing polymer-based nanomedicines to give them suitable characteristics. It covers the synthesis of polymers; the principles used to associate drugs and to achieve both drug loading and controlled release; the approaches developed to control interactions of the nanoparticles with proteins while they are in biological fluids and to control the in vivo fate of the nanoparticles; nanotoxicological aspects including the design of nanotheranostics with therapeutic and diagnostic tools in the same nanoparticles. The last section of the book gives prospective views on the development of this type of nanomedicines, considering their registration and potential market. This comprehensive book is fit for a wide audience, written by prominent researchers and top experts in the field of nanomedicines who share a web of established knowledge, point out unanswered questions, and discuss the field's bottlenecks in order to succeed in the development of nanomedicines made of polymer nanoparticles and to translate these into the clinic. The panel of authors reflects the different disciplines that cover the whole process of research and development of a polymer nanomedicine. Researchers and other field-related professionals can refer to the book from the early stages of the conception of a new nanomedicine to the later stages of development, including the preparation of registration, which needs to be started as early as possible, taking in mind that all choices will need to be justified. Developers will also find resources in this book to apply quality-by-design approaches when designing and developing polymer-based nanomedicines. Finally, we believe that this book, which aims to give a thorough picture of the state-of-the-art in the field of polymeric nanoparticles, will become a favorite book for anyone interested in the development of these nanomedicines.
988			_aEBOOK, EBSPRINGER
650	0	7	_aNanotecnología _2embne _9158453
650	0	7	_aBiotecnología _2embne _9140931
650		7	_9143820 _aIngeniería biomédica _2embne
700	1		_aVauthier, Christine. _eeditor literario _9101572 _0Local
700	1		_aPonchel, Gilles. _eeditor literario _9101573 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-41421-8zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12981242 _b10-10-17 _c08-03-17
942			_2lcc _cLE
945			_g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11603082 _z06-04-17
998			_b06/2020 _dz _eu _feng _ggw _h0