000			03963nam a22003855i 4500
001			86616
003			ES-MaUEC
005			20230207040606.0
007			cr nn 008mamaa
008			160609s2016 ja s 000 0 eng d
020			_a9784431560272
040			_aES-MaUEC
050		4	_aQR186 _b.S96 2016 EB
082	0	4	_a616.079
245	0	0	_aSynthetic Immunology _cedited by Takeshi Watanabe, Yousuke Takahama
260			_aTokyo _bSpringer Japan _c2016
300			_a1 recurso en línea (XI, 200 p.) _b45 ilustraciones, 41 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1. Overview (Michael Reth) -- 2. Development and regeneration of HSCs (Hiromitsu Nakauchi) -- 3. Development and regeneration of T cells (Hiroshi Kawamoto) -- 4. Controlling the thymus development (Richard Boyd) -- 5. Artificial thymus microenvironment (JC Zuniga-Pflucker) -- 6. Controlling lymph node development (Sergio Lira) -- 7. Artificial lymph nodes (Takeshi Watanabe) -- 8. Lymph nodes as surrogate organ (Eric Lagasse) -- 9. Tissue reconstitution by 3D bio-printer (Makoto Nakamura) -- 10. Reconstitution of human immune system in the mouse (Fumihiko Ishikawa)
520			_aThis book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system. Immunology has developed rapidly over the last 50 years through the incorporation of new methods and concepts in cell and molecular biology, genetics, genomics and proteomics. This progress is the result of works by many excellent researchers all over the world. Currently, immunological research has accumulated detailed knowledge on basic mechanisms of immunity and is in the process to change medical practices. Yet, due to the enormous complexity of the immune system, many aspects on the regulation and function of this system remain unknown. Synthetic biology uses gain-of-function rather than loss-of-function approaches. The goals of synthetic biology can be described in a simple phrase zrebuild, alter, and understand," namely, to rebuild minimal functional systems using well-defined parts from nature and then to perturb the system to understand its working principles. Given the richness of accumulated knowledge in molecular and cellular mechanisms of the immune system, we now begin adapting the concepts of synthetic biology to immunology. An immune response is a spatiotemporal phenomenon occurring at a given time and at a specialized place in the body. One goal of synthetic immunology is to reconstruct artificial microenvironments for better understanding of an immune response. We hope this yet-to-be-experimental approach of synthetic immunology and the compilation of this book will aid our further understanding of the immune system and future devising the tools to manipulate the immune system for therapy and prevention of the diseases
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aRespuesta inmune _9162846 _0comprobar BNE20040171133 _2embne
650		7	_aInmunología _0comprobar BNE19900958507 _2embne _9138330
700	1		_aWatanabe, Takeshi _eeditor literario _9100466 _0Local
700	1		_aTakahama, Yousuke _eeditor literario _985652 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-56027-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9784431560272
907			_a.b12958943 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b08-06-17 _cm _dz _eu _feng _gja _h0
945			_aQR186 .S96 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1160041x _z06-04-17
999			_c86616 _d86616 _x1