000			02968nam a2200325 c 4500
001			86615
003			ES-MaUEC
005			20230207040606.0
008			160725s2016 ja | s |||| 0|eng d
020			_a9784431560241
040			_aES-MaUEC
050		4	_aRB131 _b.M378 2016 EB
082	0	4	_a614.5999
100	1		_aMaru, Yoshiro _9100465 _0Local
245	1	0	_aInflammation and Metastasis _cby Yoshiro Maru
260			_aTokyo _bSpringer Japan _c2016
300			_a1 recurso en línea (XX, 505 p.) _b67 ilustraciones, 22 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aThis book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complicated mechanisms of metastasis as well as to interpret therapeutic targets. The book includes the topic of the emerging roles of endogenous TLR4 ligands whose functions are shared intriguingly by metastasis and auto-inflammatory diseases such as rheumatoid arthritis. For example, most cancer therapies established so far are effective initially. However, they eventually face the great obstacles of drug resistance, immune evasion, and metastatic progression. One of the endogenous TLR4 ligands is thought to contribute to all three processes. The most important features of the book are to explain a concept of homeostatic inflammation, disturbance of which in the lungs gives rise to the establishment of a pre-metastatic pulmonary microenvironment based on primary tumor-mediated hijacking of the innate immune defense system against respiratory infection. In addition, structure-based thinking is another important feature of this book. It is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, in the center of which cancer is located. Given the proposal of precision medicine by President Obama in the United States in 2015 and the recent success of immune-modulator-based therapy, this book will appeal to researchers in a variety of fields with the title of the book connecting the worst disease (metastasis) and the most fundamental event (inflammation) that is common to many diseases.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aInflamación _0comprobar BNE19974047195 _2embne _9153270
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-56024-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9784431560241
907			_a.b12958931 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b22-05-17 _cm _dz _ef _feng _gja _h0
945			_aRB131 .M378 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11600408 _z06-04-17
999			_c86615 _d86615 _x1