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020			_a9784431558736
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050		4	_aQP624 _b.D63 2016 EB
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245	0	0	_aDNA Replication, Recombination, and Repair : _bMolecular Mechanisms and Pathology _cedited by Fumio Hanaoka, Kaoru Sugasawa
250			_a1st ed.
260			_aTokyo _bSpringer Japan _c2016
300			_a1 recurso en línea (IX, 555 p.) _b79 ilustraciones, 18 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPart 1 DNA Replication -- 1 Molecular Mechanism of DNA Replication -- 2 Characteristics of Metazoan DNA Replication Origins -- 3 DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replication -- Part 2 DNA Recombination -- 4 Mechanism of Homologous Recombination -- 5 Regulation of Recombination by Chromatin -- 6 Homologous Recombination During Meiosis -- Part 3 DNA Repair -- 7 DNA Damage Recognition and Repair in Mammalian Global Genome Nucleotide Excision Repair -- 8 The Fanconi Anemia Pathway and Interstrand Crosslink Repair -- 9 The Crossroads of Ubiquitination and DNA Repair: A Structural Perspective -- Part 4 Genome Instability and Mutagenesis -- 10 Genome Instability of Repetitive Sequence: Lesson From the Ribosomal RNA Gene Repeat -- 11 Translesion DNA Synthesis and Damage Tolerance Pathways -- 12 Mismatch Repair -- 13 Non-Homologous End-Joining -- Part 5 Chromosome Dynamics and Functions -- 14 Centromeric Chromatin and Kinetochore Assembly in Vertebrate Cells -- 15 CST Complex and Telomere Maintenance -- Part 6 Cell Cycle and Checkpoints -- 16 Signaling of DNA Replication Stress Through the ATR Checkpoint -- 17 Spindle Assembly Checkpoint: Its Control and Aberration -- 18 Molecular Insights Into the Regulation of Apoptosis and Cellular Senescence and Their Implications for Cancer -- Part 7 Interplay with Transcription and Epigenetic Regulation -- 19 DNA Replication and Histone M odification -- 20 Establishment and Maintenance of DNA Methylation -- 21 Active DNA Demethylation in Development, Human Disease, and Cancer -- BM Index
520			_aThis book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1), DNA Replication; Part 2 (Chapters 4), DNA Recombination; Part 3 (Chapters 7), DNA Repair; Part 4 (Chapters 10), Genome Instability and Mutagenesis; Part 5 (Chapters 14), Chromosome Dynamics and Functions; Part 6 (Chapters 16), Cell Cycle and Checkpoints; Part 7 (Chapters 19), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aADN _xReplicación _9301511 _0comprobar BNE20003536276 _2embne
650		7	_aADN recombinante _0comprobar BNE19900989961 _2embne _9140814
700	1		_aHanaoka, Fumio _eeditor literario _0Local _9100436
700	1		_aSugasawa, Kaoru. _eeditor literario _9100437 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-55873-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9784431558736
907			_a.b12958773 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b07-06-17 _cm _dz _eu _feng _gja _h0
945			_aQP624 .D63 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11600299 _z06-04-17
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