000			03902nam a22003735i 4500
001			86594
003			ES-MaUEC
005			20230207040606.0
007			cr nn 008mamaa
008			160106s2016 ja s 000 0 eng d
020			_a9784431558521
040			_aES-MaUEC
050		4	_aQP552.H43 _bH43 2016 EB
082	0	4	_a571.6
245	0	0	_aHeat Shock Factor _cedited by Akira Nakai
250			_a1st ed.
260			_aTokyo _bSpringer Japan _c2016
300			_a1 recurso en línea (VIII, 301 p.) _b73 ilustraciones, 14 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1 Proteostasis and adaptation to high temperature stress -- 2 Structure and function of the HSF family members -- 3 Regulation of HSF activation and repression -- 4 Transcriptional regulation by HSF -- 5 HSF1 regulation in aging and its role in longevity -- 6 HSF modulates neural development under normal and stress conditions -- 7 HSF maintains sensory organs -- 8 HSF is required for gametogenesis -- 9 HSF Regulates Immune and Inflammatory Response -- 10 Heat shock factors modulate circadian rhythms -- 11 HSF inhibits the progression of age-related neurodegenerative diseases -- 12 HSF and heart diseases -- 13 HSF supports cancer -- 14 HSF1 activation by small chemical compounds for the treatment of neurodegenerative diseases.
520			_aThis book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and pathological roles of HSF have been extensively studied in fruit fly, worm, and mouse models. It has been revealed that HSF plays roles in development of the brain, reproductive and sensory organs, and in ageing, inflammation, and circadian rhythm. Analysis of the mechanisms have uncovered that HSF exerts a wide range of effects on gene expression and epigenetic status on the whole genome. Moreover, loss or gain of HSF function is also closely related to protein-misfolding diseases including neurodegenerative diseases, psychiatric diseases, heart diseases, and cancers. Therefore, HSF is now thought to be a promising therapeutic target for treatment of these refractory diseases. For undergraduate students, this is a highly understandable source of information on heart shock response and HSF, covering the basis of HSF biology, the physiological role of HSF, and disease associated with HSF function. This book not only serves as a guide to the heat shock response and HSF for students and young researchers in other fields, but also is a cornerstone for future work in the field related to the heat shock response and HSF
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aProteínas de choque térmico _0comprobar BNE20021340356 _2embne _9160151
700	1		_aNakai, Akira. _eeditor literario _9100426 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-55852-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9784431558521
907			_a.b12958724 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b07-06-17 _cm _dz _eu _feng _gja _h0
945			_aQP552 .H43 H43 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11600263 _z06-04-17
999			_c86594 _d86594 _x1