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001			86578
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008			160204s2016 ja | s |||| 0|eng d
020			_a9784431557081
040			_aES-MaUEC
050		4	_aRC924.5.S34 _b2016 EB
082	0	4	_a616.5
245	0	0	_aSystemic sclerosis _cedited by Kazuhiko Takehara, Manabu Fujimoto, Masataka Kuwana
250			_a1st ed
260			_aTokyo _bSpringer _c2016
300			_a1 recurso en línea (VIII, 247 p.) _b28 ilustraciones, 7 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1 -- Fibrosis: overview 2 -- Autoimmunity in systemic sclerosis: Overview 3 -- Endothelial progenitor cell 4 -- Animal models of systemic sclerosis 5 -- Genetics of Systemic Sclerosis 6 -- Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis 7 -- Interleukin-6 in the Pathogenesis of Systemic Sclerosis 8 -- Epigenetics 9 -- Transforming Growth Factor-ß and Connective Tissue Growth Factor 10 -- Endothelin 11 -- The Role of B cells in Systemic Sclerosis 12 -- Fli1 13 -- Biomarker 14 -- Autoantibodies in Systemic Sclerosis
520			_aThis book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		7	_aEsclerodermia sistémica _9166494 _0comprobar BNE20061576526 _2embne
650		7	_aReumatismo _0comprobar BNE19900963873 _2embne _9138755
650		7	_aMedicina interna _0comprobar BNE19900959227 _2embne _9138387
700	1		_aTakehara, Kazuhiko _eeditor literario _9100402 _0Local
700	1		_aFujimoto, Manabu _eeditor literario _9100403 _0Local
700	1		_aKuwana, Masataka _eeditor literario _9100404 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-55708-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9784431557081
907			_a.b12958566 _b10-10-17 _c21-11-16
988			_aSpringer_Medicine_2016
998			_am _a_alco _a_vill _b08-06-17 _cm _dz _eb _feng _gja _h0
945			_aRC924.5 .S34 S97 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11600135 _z06-04-17
999			_c86578 _d86578 _x1