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020			_a9783658127947
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050		4	_aRC280.S5 _b2016 EB
082	0	4	_a616.5
100	1		_aSand, PD Dr. Michael. _9100099 _0Local
245	1	0	_aMicroRNAs in malignant tumors of the skin : _bFirst steps of tiny players in the skin to a new world of genomic medicine _cby PD Dr Michael Sand
264		1	_aWiesbaden _bSpringer Fachmedien Wiesbaden _c2016
300			_a1 recurso en línea (XI, 245 páginas) _b1 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction -- Objectives of this work -- Summary and discussion of this work -- Closing remarks -- Paper 1: Expression levels of the microRNA processing enzymes Drosha and Dicer in epithelial skin cancer -- Paper 2: Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA- induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1 and TARBP2 in epithelial skin cancer -- Paper 3: Expression of microRNAs in basal cell carcinoma -- Paper 4: Microarray analysis of microRNA expression in cutaneous squamous cell carcinoma -- Paper 5: The miRNA machinery in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi -- Paper 6: Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi -- Paper 7: Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi -- Paper 8: MicroRNAs and the skin: tiny players in the body�s largest organ -- Paper 9: microRNA in non-melanoma skin cancer.
520			_aMichael Sand gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin. This book is a postdoctoral thesis on miRNAs in cutaneous malignant melanoma and non-melanoma skin cancer with a focus on the miRNA processing machinery and miRNA expression profiling. The research presented in this book was performed in the Dermatologic Surgery Section at the Department of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin. Contents MicroRNAS Basal cell carcinoma Cutaneous squamous cell carcinoma Cutaneous malignant melanoma Target Groups Researchers and students in the field of medicine, dermatology, molecular biology, pathology Dermatologist and pathologist About the Author Michael Sand, MD studied medicine at the Ruhr-University of Bochum / Germany, Harvard Medical School Boston and the University of California, San Diego (UCSD). After board certification in Dermatology, Venereology and Emergency Medicine at the Ruhr-University Bochum / Germany he and his team started to investigate the role of microRNA in the skin. He is currently an attending physician in the Department of Plastic Surgery, Catholic Clinics of the Ruhr Peninsula, Essen, Germany with a clinical focus on surgical therapy of skin cancer and a research focus on the role of microRNAs in malignant skin tumors.
650		7	_aPiel _xCáncer _9205316
650		7	_aCáncer _xInvestigación _2embne _9182523
710	2		_aSpringerLink (Online service) _0Local _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-658-12794-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783658127947
907			_a.b12956867 _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11615576 _z30-06-17
988			_aSpringer_Medicine_2016
998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ef _feng _ggw _h0
999			_c86408 _d86408 _x1