000			02651nam a22003855i 4500
001			86369
003			ES-MaUEC
005			20240611040147.0
007			cr nn 008mamaa
008			160923s2016 gw | s |||| 0|eng d
020			_a9783319469065
040			_aES-MaUEC
050		4	_aQR185.8.I56 _bL37 2016 EB
082	0	4	_a616.079
100	1		_aLasek, Witold _0Local _0http://id.loc.gov/authorities/names/n2017183280 _1http://viaf.org/viaf/102024087 _9100039
245	1	0	_aInterleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology _cby Witold Lasek, Radoslaw Zagozdzon
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (VII, 75 páginas) _b6 ilustraciones
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSpringerBriefs in Immunology _x2194-2773
520			_aThis book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).
650		7	_aInmunología _2embne _9138330
700	1		_aZagozdzon, Radoslaw _0Local _0http://id.loc.gov/authorities/names/n2017183279 _1http://viaf.org/viaf/5478149296284080670001 _9100040
710	2		_aSpringerLink (Online service) _0Local _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-46906-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319469065
907			_a.b12956478 _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11615527 _z30-06-17
988	0	0	_aEBOOK, EBSPRINGER, GOBI_sep2018
988			_aEbook_one2one
998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ef _feng _ggw _h0
999			_c86369 _d86369 _x1