000			03318nam a22003735i 4500
988			_aSpringer_Medicine_2016
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008			161028s2016 gw | s |||| 0|eng d
020			_a9783319437545
040			_aES-MaUEC
050		4	_aRM138 _b2016 EB
082	0	4	_a618.92
245	1	0	_aFundamentals of Pediatric Drug Dosing _cedited by Iftekhar Mahmood, Gilbert Burckart
260			_aCham _bSpringer International Publishing _bImprint _bAdis _c2016
300			_a1 recurso en línea (VIII, 146 páginas) _b12 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1. Pediatric Drug Development and the Regulatory Changes that are Creating the Science of Pediatric Dosing -- 2. Pediatric Physiology -- 3. Developmental Pharmacology: Impact on Pharmacokinetics and Pharmacodynamics of Drugs -- 4. Pediatric Clinical Trial Design and Dosing -- 5. Applicaton of Allometric Principles in Pediatric Drug Development -- 6. Population Pharmacokinetics in Pediatric Drug Development -- 7. Scaling Dose-Exposure-Response from Adults to Children -- 8. Applications of Physiologically-Based Pharmacokinetic (PBPK) Models for Pediatric Populations -- 9. Perinatal Pharmacology and Maternal/Fetal Dosing.
520	3		_aFocused on pediatric physiology, pharmacology, pharmacokinetics and pharmacodynamics, this book illustrates the differences between the pediatric population and adults; knowledge of extreme importance not only during pediatric drug development but also in the clinical practice. Physicians, nurses, clinical pharmacologists, researchers and healthcare professionals will find this an invaluable resource.� With the advent of pediatric exclusivity, and requirements to conduct clinical studies in children, an emphasis has been placed on finding a safe and efficacious dose of a drug in children. Children are not �small adults�, and drug dosing in this population requires special consideration. There are subtle physiological and biochemical differences among neonates, infants, children, adolescents and adults and dosing in pediatrics requires proper understanding of these factors. Furthermore, dosing in children, as in adults, should be based on pharmacokinetic and pharmacodynamic data. This is an evolving area, as pediatric pharmacokinetic studies are becoming mandatory for getting approval of new drugs in this population.
650		7	_aFarmacología pediátrica _0comprobar BNE19900959047 _2embne _9673518
700	1		_aMahmood, Iftekhar. _eeditor literario _999948 _0Local
700	1		_aBurckart, Gilbert _eeditor literario _0Local _999949
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-43754-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319437545
907			_a.b12955991 _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aRM138 .F863 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11597987 _z06-04-17
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