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020 _a9783319420592
040 _aES-MaUEC
050 4 _aRC280.C6
_bN66 2016 EB
082 0 4 _a614.5999
245 0 0 _aNon-coding RNAs in Colorectal Cancer
_cedited by Ondrej Slaby, George A Calin
260 _aCham
_bSpringer International Publishing
_c2016
300 _a1 recurso en línea (VIII, 252 páginas)
_b19 ilustraciones, 13 ilustraciones en color
336 _aTexto (visual)
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
490 1 _aAdvances in Experimental Medicine and Biology
_x0065-2598
_v937
505 0 _aIntroduction.-Part I Non-coding RNAs: biology and implications in colorectal cancer pathogenesis.-Non-coding RNAs: classification, biology and functioning.-Involvement of non-coding RNAs in hallmarks and key signaling pathways of colorectal cancer.-MicroRNAs and inflammation in colorectal cancer -- Interplay between transcription factors and microRNAs regulating epithelial-mesenchymal transitions in colorectal cancer -- Non-coding RNAs functioning in colorectal cancer stem cells -- MicroRNA Methylation in Colorectal Cancer -- Polymorphisms in non-coding RNA genes and their targets sites as risk factors of sporadic colorectal cancer -- Part II Non-coding RNAs: new class of biomarkers in colorectal cancer -- Non-coding RNAs as biomarkers for colorectal cancer screening and early detection -- Circulating non-coding RNAs as biomarkers in colorectal cancer -- Non-coding RNAs enabling prognostic stratification and prediction of therapeutic response in colorectal cancer patients -- Part III Non-coding RNAs: therapeutic targets and colorectal cancer therapeutics -- Involvement of non-coding RNAs in chemo- and radioresistance of colorectal cancer -- Non-coding RNAs: therapeutic strategies and delivery systems -- MicroRNAs as therapeutic targets and colorectal cancer therapeutics -- Summary -- Index
520 3 _aThis is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology
710 2 _aSpringerLink (Online service)
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988 _aEBOOK, EBSPRINGER
650 7 _aColon
_xCáncer
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_2embne
650 7 _aCáncer
_xInvestigación
_0comprobar BNE19901364217
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_9182523
650 7 _aGenética humana
_0comprobar BNE19900986777
_2embne
_9140562
700 1 _aSlaby,́ Ondrěj
_d1981-
_0no2007091872
_eeditor literario
_999845
_0Local
700 1 _aCalin, George A.
_q(George Adrian)
_0nb2016019120
_eeditor literario
_999846
_0Local
830 0 _aAdvances in Experimental Medicine and Biology
_x0065-2598
_v937
_9133153
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-42059-2
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901 _ai9783319420592
907 _a.b12955395
_b20-11-17
_c21-11-16
998 _am
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