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020			_a9783319416793
040			_aES-MaUEC
050		4	_aQP572.M44 _b2016 EB
082	0	4	_a616
100	1		_aCardinali, Daniel Pedro _0Local _999814
245	1	0	_aMa Vie en Noir : _bFifty Years with Melatonin and the Stone of Madness _cby Daniel Pedro Cardinali
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XIII, 301 páginas) _b119 ilustraciones, 91 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSpringer Biographies
505	0		_aPreface - A Contagious Stone? -- Chapter 1 - Brief History of the Stone of Madness -- Chapter 2 - The Pre-Scientific Stage of the Pineal Gland -- Chapter 3 - The Beginnings of the Pineal Scientific Era: Since the Late Nineteenth Century to Melatoninś Discovery -- Chapter 4 - Sleep / Wake Cycle. History and Facts -- Chapter 5 -When this Chronicler Enters this Story: the '60 -- Chapter 6 - The Stone of Madness as a Neuroendocrine Organ and Model: '70 -- Chapter 7 - Peripheral Innervation of the Neuroendocrine-immune System: The Challenges to Change a Physiological Paradigm -- Chapter 8 - Melatonin as a Potential Therapeutic Agent: the 80�s -- Chapter 9 - Melatonin as a chronobiotic that opens "the Gates of Sleep": '90 -- Chapter 10 - elatonin and "Diseases of the Soul": The Stone of Madness Comes Back -- Chapter 11 - XXI Century: The 24/7 Society as an Environmental Mutation -- Chapter 12 - Melatonin as a Medicament for the 24/7 Society. Metabolic Syndrome -- Chapter 13 - Melatonin as a Medicament for the 24/7 Society. Normal and Pathological Aging -- Chapter 15 - Melatonin as a Nutraceutical -- Epilogue.
520	3		_aI wrote this book urged by the overwhelming desire that arises towards the end of life to recapitulate the past. My goal was to summarize my experience of practicing science at the end of the 20th and early 21st centuries in Argentina, a country located far away from the world�s leading scientific centers. In the book, I summarize the intricacies of the pineal gland (zthe stone of madnessy) as historical, mystical and medical entity and its entry in contemporary medicine with the description of melatonin. I also reflect on how being associated with an unexplored subject at the beginning of their scientific career impacts the life of a scientist throughout their entire life. Today we know that in humans pineal melatonin begins is released every day late in the evening, and there is evidence that it is the trigger for the sleep process. But the most exciting aspect of melatonin is that it is a substance that is present in all living creatures, from unicellular organisms to plants and higher mammals, a fact that evinces its importance for life. Further, the neuroprotective action of melatonin promises to be crucial for the control of neurodegenerative diseases we face as a pandemic in this century. The discoverer of melatonin, Aaron Lerner, based its name on melano, the Greek word for black, because of its effect on the pigment cells of the skin. As in "La vie en rose", the immortal Edith Piaf song written in 1946, my lifelong work with melatonin could well be called "Ma vie en noir".
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650		7	_aFisiología humana _0comprobar BNE19900979803 _2embne _9140024
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-41679-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319416793
907			_a.b12955255 _b10-10-17 _c21-11-16
988			_aSpringer_Medicine_2016
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP572.M44 C373 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11597422 _z06-04-17
999			_c86247 _d86247 _x1